Website Design, Hosting, Internet Access, Business Solutions, Web Site, Got2Web Internet Services Rutland Vermont
Company Description:
got2web internet services of rutland vermont provides complete internet solutions, including design, hosting, internet access and business solutions. home page.
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Company Address:
212 Pearl St,RUTLAND,VT,USA
ZIP Code: Postal Code:
05701-2319
Telephone Number:
8027730126 (+1-802-773-0126)
Fax Number:
8027730126 (+1-802-773-0126)
Website:
www. got2web. com
Email:
USA SIC Code(Standard Industrial Classification Code):
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Spotlight on GOT2 in Cancer Metabolism - PMC GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited
GOT2 glutamic-oxaloacetic transaminase 2 [Homo sapiens (human)] - Gene . . . Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles The two enzymes are homodimeric and show close homology
GLUTAMATE OXALOACETATE TRANSAMINASE, MITOCHONDRIAL; GOT2 - OMIM The GOT2 gene encodes the mitochondrial glutamate oxaloacetate transaminase, also called aspartate aminotransferase (EC 2 6 1 1), a pyridoxal 5-prime phosphate (vitamin B6)-dependent enzyme that catalyzes the reversible interconversion of oxaloacetate and glutamate into aspartate and alpha-ketoglutarate
GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and . . . Mechanistically, silencing of GOT2 enhanced glutaminolysis, nucleotide synthesis, and glutathione synthesis by reprogramming glutamine metabolism to support the cellular antioxidant system, which activated the PI3K AKT mTOR pathway to contribute to HCC progression
GOT2 | Abcam GOT2 Function Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD (H) redox balance Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism
Got2 - glutamatic-oxaloacetic transaminase 2, mitochondrial Gene Enables L-aspartate:2-oxoglutarate aminotransferase activity Acts upstream of or within dicarboxylic acid metabolic process Located in mitochondrion Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system