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- GOT2 - Wikipedia
GOT2 is a dimer containing two identical subunits that hold overlapping subunit regions The top and sides of the enzyme are made up of helices, while the bottom is formed by strands of beta sheets and extended hairpin loops
- Spotlight on GOT2 in Cancer Metabolism - PMC
GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited
- Mitochondrial glutamine metabolism via GOT2 supports . . . - Nature
Here, we show that mitochondrial glutamine metabolism regulates senescence in human pancreatic ductal adenocarcinoma (PDAC) cells Glutamine deprivation or inhibition of mitochondrial aspartate
- GOT2 glutamic-oxaloacetic transaminase 2 [Homo sapiens (human)] - Gene . . .
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles The two enzymes are homodimeric and show close homology
- GLUTAMATE OXALOACETATE TRANSAMINASE, MITOCHONDRIAL; GOT2 - OMIM
The GOT2 gene encodes the mitochondrial glutamate oxaloacetate transaminase, also called aspartate aminotransferase (EC 2 6 1 1), a pyridoxal 5-prime phosphate (vitamin B6)-dependent enzyme that catalyzes the reversible interconversion of oxaloacetate and glutamate into aspartate and alpha-ketoglutarate
- GOT2 | Abcam
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD (H) redox balance Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism
- GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and . . .
Mechanistically, silencing of GOT2 enhanced glutaminolysis, nucleotide synthesis, and glutathione synthesis by reprogramming glutamine metabolism to support the cellular antioxidant system, which activated the PI3K AKT mTOR pathway to contribute to HCC progression
- Hepatic glutamic-oxaloacetic transaminase promotes mitochondrial . . .
The mitochondrial enzyme, glutamic-oxaloacetic transaminase (GOT2), catalyzes the reaction between oxaloacetate and glutamate generating aspartate and alpha-ketoglutarate
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