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Paolo Tarantino: Recent ADCs took a median time of 7 years from . . . Early risk: ADCs have lower Phase 1–2 (46%) and Phase 2–3 (24%) success due to off-target toxicity, complex PK, and biomarker variability Late-stage strength: Once in Phase 3, ADCs achieve 82% approval, more than 2x oncology’s average (36%) thanks to smarter trial designs and biomarker strategies
Advancing Phase 3 Trials for ADC Cancer Therapies - qps. com This summer, three pharma giants — Merck Co , Gilead Sciences, and AstraZeneca — have all been competing to advance the next generation of ADC cancer therapies, running a total of 33 ADC-related Phase 3 clinical trials across companies
Antibody-drug conjugates (ADCs): Oncologys next revolution | ZS For ADC monotherapies in phase 3 trials (not pictured), the PTRS is even higher at 53%, compared with 41% for oncology overall The comparatively high PTRS of ADCs helps explain both the frequency and size of deals we’ve seen in 2023 and 2024
Pfizer reveals ADC data prompting Phase 3 lung cancer trial Pfizer unveiled updated clinical results that substantiate its accelerated approach The data revealed that approximately 20% of lung cancer patients treated with sigvotatug vedotin experienced a significant reduction in tumor size, with shrinkage of at least 30%
Why are clinical development success rates falling? - Norstella Phase transition data from Citeline for the 10-year period between 2014ؘ and 2023 show that the average likelihood of approval (LOA) for a new Phase I drug is now just 6 7% This has steadily fallen in each analysis to an all-time low
Will the ADC Wave Continue in 2025? - DCAT Value Chain Insights Deal-making by the large pharma companies in antibody drug conjugates (ADCs) to build their in product portfolios in oncology has been on the upsurge, but will the ADC wave continue in 2025? A look at recent deals and what may lie ahead By Patricia Van Arnum, Editorial Director, DCAT, pvanarnum@dcat org
Blackstone Reports Fourth Quarter and Full Year 2024 Results Blackstone has declared a quarterly dividend of $1 44 per share to record holders of common stock at the close of business on February 10, 2025 This dividend will be paid on February 18, 2025 Blackstone will host its fourth quarter and full year 2024 investor conference via public webcast on January 30, 2025 at 9:00 a m ET
Clinical Development Success Rates and Contributing Factors 2011–2020 For Phase III transition success rates, Oncology had the lowest transition success rate (47 5%, n=495) As seen in Figure 4, the Phase III success rates for the remaining 13 specific disease areas were each above 50%
Oncology and Haematology - AstraZeneca For a list of new molecular entities and indications in development, see pages 7-11 of the Clinical Trials Appendix that accompanied AstraZeneca’s Q1 2024 results
Clinical Trial Success Rate in Lymphoma: Fate of Trials and Agents from . . . The success rate from phase 1 to phase 2, phase 2 to phase 3, and phase 3 to approval for lymphoma were 94 7%, 10 6% and 48 4%, respectively The overall success rate from agents evaluated in phase 1 to approval was 5 1% (95%CI: 3 7%-6 6%)