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- Clinical Development Success Rates and Contributing Factors 2011–2020
A total of 12,728 clinical and regulatory phase transitions were recorded and analyzed from 9,704 development programs over the last decade (2011–2020), across 1,779 companies in the Biomedtracker database
- Clinical Development Success Rates and Contributing Factors 2011-2020 - BIO
The report includes comparisons of success rates across indications and modalities, regulatory factors, and predictive factors driving successes and failures in drug development
- Clinical Development Success Rates and Contributing Factors. . . | CPHI . . .
QLS Advisors applied machine learning to “uncover underlying drivers of success” in the 9,704 clinical drug development programs included in the study, “Clinical Development Success Rates and Contributing Factors, 2011-2020,” published 17 February 2021
- Trends in clinical success rates and therapeutic focus - PubMed
Trends in risks associated with new drug development: success rates for investigational drugs DiMasi JA, Feldman L, Seckler A, Wilson A Clin Pharmacol Ther 2010 Mar;87 (3):272-7 doi: 10 1038 clpt 2009 295 Epub 2010 Feb 3 PMID: 20130567 Review Therapeutic recombinant proteins: trends in US approvals 1982 to 2002
- Holistic in silico developability assessment of novel classes of small . . .
The development of novel therapeutic proteins is a lengthy and costly process, with an average attrition rate of 91% (Thomas et al Clinical Development Success Rates and Contributing Factors 2011-2020, 2021)
- Biotechnology Innovation Organization | BIO
This report examines success rates across ~10,000 clinical program transitions by therapeutic area as well as three unique categories: rare diseases, chronic high prevalence diseases, and programs utilizing selection biomarkers The results show dramatic differences between disease groups and modalities Some Key Findings:
- Clinical Development Success Rates and Contributing . . .
Key Takeaways The overall likelihood of approval (LOA) from Phase I for all developmental candidates over 2011 2020 was Phase II Development remains the largest hurdle in drug Development , with just of candidates achieving this critical phase transition
- Clinical Development Success Rates and Contributing Factors 2011-2020
metrics that influence clinical success rates were applied in a predictive capacity to produce risk assessments and evaluations of R D assets with increased accuracy Key Takeaways • The overall likelihood of approval (LOA) from Phase I for all developmental candidates over 2011–2020 was 7 9%
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