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Toxicity and Safety Analysis of Polyhexamethylene Guanidine: A Comprehensive . . . Abstract: Polyhexamethylene guanidine (PHMG) is a commonly used disinfectant, but safety concerns have arisen due to poisoning cases This systematic review assesses the toxicity and safety of PHMG by inhalation, oral administration, skin contact, and ocular contact to determine its potential medical applications and acceptable concentration limits Searches in PubMed, ScienceDirect, CENTRAL