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Memory T‐Cell Phenotype in Cutaneous T‐Cell Lymphoma Is Modified by . . . We compared the level of GTSF1 mRNA expression between cancer and their normal adjacent tissue across 33 cancer types (Figure 1A) Our analysis demonstrated that GTSF1 is significantly overexpressed in Breast Invasive Carcinoma (BRCA), Head and Neck Squamous Cell Carcinoma (HNSC), Kidney Renal Clear Cell Carcinoma (KIRC) and Kidney Renal
285 Investigating the role of the ectopic expression of Gametocyte . . . The objective of the study is to pinpoint the role of GTSF1 on carcinogenesis and elucidate how its ectopic expression is modifying patient outcome GTSF1, a germline-cell specific gene, is an important element of the piRNA pathway
Expression of GTSF1 in cancer - Summary - The Human Protein Atlas Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0 001) association with patient survival are shown in this summary Whether the prognosis is favorable or unfavorable is indicated in brackets
Abstract 345: Cutaneous T-cell lymphoma: ectopic expression of . . . Although not officially a Cancer-Testis (CT) antigen, ectopic expression of Gametocyte Specific Factor 1 (GTSF1), presents the same advantages than CT antigens Its germline-cell restricted expression potentially makes this gene easily identifiable by the immune system and a therapeutic target with less side effects
Ectopic expression of cancer testis antigens in Cutaneous T-Cell . . . In the current work we demonstrated that a number of CT antigens are heterogeneously expressed in CTCL patients while cTAGE1, SYCP1 and GTSF1 are preferentially expressed in CTCL lesional skin when compared to benign inflammatory dermatoses or normal skin
Developing Novel Cellular Therapies for Cutaneous T Cell Lymphoma (CTCL . . . Gametocyte Speci c Factor 1 (GTSF1) emerged as a top candidate, as its ubiquitous over-expression across CTCL cells and highly selective expression in tumors and germinal tissues support the wide-reaching potential of this therapeutic target
Ectopic expression of cancer-testis antigens in cutaneous T-cell . . . Results: Our findings demonstrate that SYCP1, SYCP3, REC8, SPO11, and GTSF1 genes are heterogeneously expressed in patients with CTCL and patient-derived cell lines, whereas cTAGE1 (cutaneous T-cell lymphoma-associated antigen 1) was found to be robustly expressed in both
GTSF1 gene may serve as a novel potential diagnostic biomarker for . . . GTSF1 gene expression was detected in liver cancer tumor tissues, compared with in healthy controls, via reverse transcription quantitative polymerase chain reaction An adeno-associated virus vector was used to study tumor stem cell proliferation in vivo