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Tau (AT8); Phospho Tau (Ser 202, Thr 205) - ALZFORUM Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease Recognizes paired helical filament (PHF) tau Phosphorylation at serine 202 and threonine 205 is required for recognition by AT8
A Tale of Two T Cells—Slowing Tau Spread, Shredding White Matter With T cells sidelined in these CD8 knockouts, tau pathology went on the offensive By 30 weeks of age, phospho-tau had spread deeper into the brain than in CD8-intact controls (image below) Michal Schwartz of the Weizmann Institute of Science in Rehovot, Israel, noted that these findings run counter to conventional thinking
Triple Trouble: New Knock-in Turbocharges Tauopathy They accumulated hyperphosphorylated tau in their brains and lost synapses by approximately 15 months of age, but they had no tau oligomers capable of seeding aggregates Such “seeds” are a hallmark of human tauopathies Recognizing the need for models with more robust pathology at a younger age, the authors engineered the new triple-knock-ins
LY3954068 | ALZFORUM LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau No information is available about the makeup of LY3954068
Better Diagnosis with Blood Test Detecting Only Tau Made in Brain In the December 27 Brain, Karikari reported that plasma concentration of these brain-derived forms of tau (BD-tau) tracked with cerebrospinal fluid markers of amyloid plaques and of neurofibrillary tangles, with postmortem plaque and tangle load, and with cognitive test scores better than plasma total tau and neurofilament light, the currently available blood markers of neurodegeneration
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time It showed that ApoE3Ch clings onto tau monomers immobilized on sensor chips approximately eight times more tightly than does wild-type ApoE3 Similarly, in neuroblastoma cells, glutathione S-transferase-labelled tau and GFP-tagged ApoE3Ch bound tightly (image at right)
Widely Used Tau Seeding Assay Challenged - ALZFORUM Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey In a preprint on bioRxiv, researchers led by Eckhard Mandelkow at the German Center for Neurodegenerative Diseases, Bonn, question whether a widely used
Tau (CP-13) - ALZFORUM This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202 Recognizes tau phosphorylated at serine 202 Immunoreactivity present in Alzheimer’s disease and other tauopathies Immunoreactivity absent in
Tau (MC-1) - ALZFORUM The interaction of MC-1 with recombinant tau suggests that post-translational modifications are not required to generate the MC-1 epitope However, it remains possible that post-translational modifications influence the ability of tau to adopt or maintain the conformation seen by MC-1