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Exploring Macrophage Contribution to Vascular Calcification in . . . By elucidating the cellular and molecular mechanisms underpinning macrophage-mediated calcification, this review aims to provide insights into the dual roles of macrophages in atherosclerosis and their significance as potential therapeutic targets
Frontiers | The role of macrophages in vascular calcification . . . This review systematically summarizes the mechanisms of macrophage polarization in VC, discusses the application of macrophage-related biomarkers and imaging techniques in diagnosis, and highlights therapeutic strategies targeting macrophage polarization, recruitment, and activation
Role of macrophages in vascular calcification: From the perspective of . . . The recruitment of circulating monocytes to the vascular wall, where they differentiate into macrophages and infiltrate the wall, is a crucial step in the development of vascular diseases such as atherosclerosis, aortic aneurysm, and VC
Macrophage death in atherosclerosis: potential role in calcification Reducing macrophage cell death and or increasing their efferocytosis capacity could be a novel therapeutic strategy to reduce the formation of a necrotic core and calcification and thereby improving atherosclerotic plaque stability
Exploring Macrophage Contribution to Vascular Calcification in . . . By elucidating the cellular and molecular mechanisms underpinning macrophage‐mediated calcification, this review aims to provide insights into the dual roles of macrophages in atherosclerosis and their significance as potential therapeutic targets
The role of macrophage polarization in vascular calcification Proinflammatory macrophages, which are activated by lipid oxidation products and basic calcium phosphate crystals, secrete cytokines like TNF-α, IL-1, and IL-6 in the context of atherosclerotic calcification, thus facilitating the process of vascular calcification
Exploring Macrophage Contribution to Vascular Calcification in . . . By elucidating the cellular and molecular mechanisms underpinning macrophage-mediated calcification, this review aims to provide insights into the dual roles of macrophages in atherosclerosis and their significance as potential therapeutic targets