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Pathology Outlines - High grade serous carcinoma Serous tubal intraepithelial carcinoma (STIC) (90% fimbria, 10% ampulla isthmus) exhibits similar histologic features; may be bilateral (10 - 20%) and multifocal Findings after neoadjuvant chemotherapy: single cells in a background of histiocytic reaction and fibrosis, clear cell change, decrease in mitotic figures, increased psammoma bodies
Pathology Outlines - p53 Differentiate serous tubal intraepithelial carcinoma (STIC) from reactive changes in epithelium of the fallopian tube or fimbriae, although serous tubal intraepithelial lesions may also have aberrant p53 phenotype and histologic differentiation is important (Int J Gynecol Pathol 2011;30:417, Int J Gynecol Pathol 2021;40:419)
Pathology Outlines - Metaplastic changes Serous tubal intraepithelial carcinoma (STIC): nuclear enlargement, increased N C ratio, lost cellular polarity, irregular nuclear stacking, small detached papillary clusters, horizontally oriented surface nuclei and intraepithelial fractures; evidence of TP53 mutation by immunohistochemistry; Ki67 index is variably increased (Mod Pathol 2017
Pathology Outlines - WHO classification Ovary - WHO classification of ovarian neoplasms, from WHO Classification of Female Genital Tumors, Chapter 1, Tumors of the Ovary, 5th Edition, 2020
Pathology Outlines - Endometriosis Endometriosis is the presence of endometrial tissue outside of endometrium and myometrium, consisting of both endometrial glands and stroma
Pathology Outlines - Fallopian tubes broad ligament Fallopian tubes broad ligamentAuthors: Doaa Atwi, M D , Jessica L Bentz, M D , Ruby Chang, M D , Hao Chen, M D , Ph D , Shaima N Elgenaid, M D , Arun Gopinath, M
Pathology Outlines - Cortical inclusion cyst For a subset of ovarian serous carcinomas (in which STIC or tubal involvement is not identified), a potential origin in epithelial inclusion cyst of Müllerian (tubal) phenotype has been postulated (Gynecol Oncol 2013;130:246, Mod Pathol 2011;24:1488, Int J Gynecol Pathol 2015;34:3)