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Liver metabolism insights into the anti-hyperuricemia effects of Polygonum cuspidatum extract increased the contents of glutamate, pyruvate and oxalacetic acid in mice, indicating that its antioxidant and Hyperuricemia activities were closely related to glucose metabolism, lipid metabolism and amino acid metabolism
Metabolomics in Hyperuricemia and Gout - MDPI In this review, we systematically summarize recent advances in metabolomic research in gout and HU in animal and human clinical studies
Polygonum cuspidatum alleviates hyperuricemia-induced . . . Hyperuricemia has been identified as a causal factor in renal injury and metabolic disorders P cuspidatum, a traditional Chinese medicine, has demonstrated potential in reducing serum uric acids and providing renoprotective effects, although its mechanisms remain to be fully elucidated
Isolation and characterization of uric acid-lowering functional . . . In present study, monomeric compounds with higher uric acid-lowering ability were isolated from P cuspidatum extract by column chromatography and thin-layer chromatography (TLC) and tested in a hyperuricemia mouse model and xanthine oxidase (XOD) inhibition assay in vitro
Fatty acid metabolism in gouty arthritis: mechanisms to therapeutic . . . A study that used lipidomics to distinguish early-onset hyperuricemia from GA revealed a systemic elevation in FA levels among patients with hyperuricemia and GA Shen et al identified dysregulated pathways and potential metabolic biomarkers for hyperuricemia and GA using serum metabolomics