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Alectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer Platinum-based chemotherapy is the recommended adjuvant treatment for patients with resectable, ALK-positive non–small-cell lung cancer (NSCLC) Data on the efficacy and safety of adjuvant
Neladalkib Shows Durable Responses in Heavily Pretreated ALK . . . Topline data from the ALKOVE-1 phase 1 2 clinical trial (NCT05384626) demonstrate neladalkib’s (NVL-655; Nuvalent) promise for treatment of patients with advanced ALK-positive non-small cell lung cancer (NSCLC) previously treated with tyrosine kinase inhibitors (TKI) The data showed an objective response rate (ORR) of 31% (95% CI: 26, 37), with an estimated durability of response of 64% and
Treatment Options for ALK+ - ALK Positive Treatment Options While our tumors share the ALK fusion gene, no two are identical There are many other differences in the tumor that may need to be considered in therapy planning Once you’re diagnosed with ALK+ lung cancer, your oncologist will determine the stage of your lung cancer and consider other factors for personalizing your treatment
Lorlatinib Versus Crizotinib in Patients With Advanced ALK . . . Lorlatinib improved progression-free survival (PFS) and intracranial activity versus crizotinib in patients with previously untreated, advanced, ALK -positive non–small cell lung cancer (NSCLC) in the phase III CROWN study Here, we report long-term outcomes from CROWN after 5 years of follow-up
Real-world treatment sequencing and effectiveness of second . . . With multiple targeted therapies approved for anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC), it is increasingly important to understand outcomes with various sequences of next-generation ALK tyrosine kinase inhibitors (TKIs) We describe contemporary sequencing patterns and treatment effectiveness of first-line (1L) and second-line (2L) treatments in
Treatment of metastatic ALK-positive non-small cell lung . . . Rearrangement in anaplastic lymphoma kinase (ALK) occurs in 4–7% of non-small cell lung cancer (NSCLC) cases Despite improved survival with tyrosine kinase inhibitors (TKIs), treatment resistance remains challenging
Nuvalent Taking Neladalkib Phase II Data in Pretreated ALK . . . NEW YORK – Nuvalent is angling for US approval in 2026 of its ALK inhibitor neladalkib for previously treated patients with ALK-positive non-small cell lung cancer after a pivotal Phase II trial showed promising efficacy The Cambridge, Massachusetts-based firm said it will discuss data from the