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Exploring the role of COX-2 in Alzheimers disease: Potential . . . This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal anti-inflammatory drugs (NSAIDs) in the management of AD
Cyclooxygenase-2 Induced the β-Amyloid Protein Deposition and Neuronal . . . Given the potential role of COX-2 in AD progression, COX-2 usually exacerbates AD via upregulating the expression of proinflammatory cytokines as an important proinflammatory factor For instance, PGE 2 treatment increases the expression of tumor necrosis factor α (TNF-α) in SH-SY5Y cells
Integrated communications between cyclooxygenase-2 and Alzheimers . . . Elevated levels of cyclooxygenase-2 (COX-2) and prostaglandins (PGs) are involved in the pathogenesis of Alzheimer's disease (AD), which is characterized by the accumulation of β-amyloid protein (Aβ) and tau hyperphosphorylation
Peroxidase Activity of Cyclooxygenase-2 (COX-2) Cross-links β-Amyloid . . . The increase Aβ-COX-2 complexes was more conspicuous in severely affected AD, where both COX-2 and Aβ blots revealed greater amounts of the immunoprecipitated complexes (p < 0 05, paired t test) This indicates that the Aβ-COX-2 complexes become more abundant as the disease progresses
Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by . . . COX enzymes metabolize arachidonic acid to prostaglandins PGG 2 and PGH 2 that are rapidly converted by cell-specific prostaglandin isomerases into different prostanoids, including PGE 2, PGF 2α, prostacyclin (PGI 2), and thromboxane A 2 (TxA 2), among others We examined the profile of several prostanoids induced by LPS in the culture medium
Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and . . . However, an increasing number of reports point to much more complex roles of COX-2 in AD Mammalian mechanistic target of rapamycin (mTOR) has been considered as a hub which integrates multiple signaling cascades, some of which are also involved in AD progression
COX-2 expression in brains of patients with familial Alzheimers . . . Possible COX-related mechanisms involved in neuronal degeneration in AD brains COX-2 and COX-1 in neurons and microglia might contribute to Aβ plaque formation by producing PGE 2 which can upregulate βAPP expression Aβ plaque could induce additional COX-2 expression in neurons creating a vicious autotoxic cycle
Frontiers | Integrated Pathways of COX-2 and mTOR: Roles in Cell . . . However, an increasing number of reports point to much more complex roles of COX-2 in AD Mammalian mechanistic target of rapamycin (mTOR) has been considered as a hub which integrates multiple signaling cascades, some of which are also involved in AD progression
Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain . . . COX-2 is the inducible isoform, rapidly expressed in several cell types in response to growth factors, cytokines, and pro-inflammatory molecules Since its discovery in the early 1990s, COX-2 has emerged as a major player in inflammatory reactions in peripheral tissues