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Defining progression independent of relapse activity (PIRA) in adult . . . The concept of PIRA (progression independent of relapse activity) in relapsing multiple sclerosis is novel and potentially disruptive The essence of this concept is that a signal of disability progression is evident in early relapsing multiple sclerosis, independent of relapses
PIRA Identified as the Most Common Form of Disability Accumulation in . . . Newly published in JAMA Neurology, a systematic review showed that progression independent of relapse activity (PIRA) is the most frequent manifestation of disability accumulation across the full spectrum of traditional multiple sclerosis (MS) phenotypes, including clinically isolated syndrome and early relapsing-remitting multiple sclerosis (RR
PIRA, Inc. PIRA is the umbrella organization representing the collective interests of the non-life insurance industry in the Philippines since 1954
PIRA - smolderingms. com Discover how addressing progression independent of relapse activity (PIRA) remains a significant unmet need in people with multiple sclerosis (MS)
Progression Independent of Relapse Activity in Multiple Sclerosis . . . Progression independent of relapse activity (PIRA) is one of the main mechanisms of disability accrual in multiple sclerosis (MS) even in people with relapsing-remitting MS (RRMS) 1 PIRA can occur at any stage of the disease and is associated with unfavorable long-term outcomes, especially if PIRA occurs early in the disease course 2 The
Progression independent of relapses (PIRA) in MS - NeuroSens These studies show that PIRA can be variously defined as worsening disability (with EDSS or a composite) independent of relapses (within a defined period or in relapse-free patients)
Understanding PIRA: will I get worse? - MSology PIRA is the hidden face of MS It is the slow process of irreversible nerve damage that occurs in parallel to the process of inflammatory flare-ups Treating inflammation with a medication may slow the process down, but current medications cannot halt or reverse PIRA
Understanding PIRA in Multiple Sclerosis - ECTRIMS Detailed exploration of studies evaluating the use of highly effective treatments have unveiled the clinical concept of progression independent of disease activity (PIRA), or an accumulation of disability in the absence of relapse-associated worsening (RAW), in multiple sclerosis (MS)