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Pathology Outlines - Myofibroblastoma Pseudoangiomatous stromal hyperplasia (PASH): Empty, anastomosing spaces within collagen Usually not mass forming Rb1 positive by immunohistochemistry and lacks del 13q14 Similar immunoprofile (CD34 positive, desmin positive [variable], ER, PR and AR positive) Solitary fibrous tumor: STAT6 positive (Pathol Res Pract 2018;214:1544)
Pathology Outlines - Hamartoma Hamartoma is a well circumscribed, often encapsulated mass composed of normal but disorganized components of breast tissue
Pathology Outlines - Anatomy PASH (pseudoangiomatous stromal hyperplasia) is specific to breast Int ra lobular Surrounds acini in TDLUs Compared to interlobular stroma, looser in appearance or even myxoid Often small numbers of inflammatory cells Lesions arising here are biphasic involving epithelial and stromal components, including fibroadenoma, phyllodes tumor
Pathology Outlines - Fibroadenoma Breast nonmalignant - Fibroadenoma is a benign biphasic tumor composed of a proliferation of both glandular epithelial and stromal components of the terminal duct lobular unit
Pathology Outlines - PAS (Periodic acid-Schiff) PAS (Periodic acid-Schiff) is a special stain, not an immunostain, that stains basement membrane (normal and in tumors), glycogen, some mucins and mucopolysaccharides
Pathology Outlines - Fibromatosis-like Fibromatosis-like metaplastic carcinoma is a variant of metaplastic carcinoma with low grade, bland, spindle cells histologically resembling fibromatosis
Pathology Outlines - Hidradenitis suppurativa Hidradenitis suppurativa is a chronic inflammatory disorder of pilosebaceous apocrine unit characterized by nodules, abscesses, fistulae and sinus tracts with scarring that most commonly affects the axillae and groin among other areas of young adults
Pathology Outlines - Transgender breast pathology Transgender individuals have a gender identity that differs from their assigned sex; the term includes gender nonbinary individuals who do not identify as exclusively male or female (Clin Breast Cancer 2019;19:e12) This article is focused on breast pathology in transmasculine (TM) people, transgender men and gender nonbinary individuals who were assigned female at birth (AFAB) but their gender