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GnRH agonists for uterine fibroids - PMC - PubMed Central (PMC) GnRH agonists act by binding to GnRH receptors and initially increasing the release of gonadotropins; this is followed by desensitisation, which leads to downregulation to a hypogonadotropic, hypogonadal state ‐ one that simulates menopause (Kessel 1988)
Pathology Outlines - Exogenous hormones Comment: The leiomyomas exhibit degenerative changes including large areas of edema, hydropic to hyaline degeneration and necrosis associated with lymphoid aggregates
Uterine Fibroids: Hiding in Plain Sight | Physiology | American . . . Uterine fibroids (leiomyomas) are present in >75% of women and can cause serious morbidity They are by far the leading cause of hysterectomy Fibroids are a complex mixture of cells that include fibroblasts and smooth muscle cells Rich in extracellular matrix, they typically arise through somatic mutations, most commonly MED12
Role of Hormones in Common Benign Uterine Lesions . . . - Springer They seem to arise in a context of hormonal imbalances due to steroid hormones, estrogen and progesterone A growing body of evidence suggests that those hormones and their receptors are key modulators in the genesis and the growth of those pathologic entities
Content of estrone and estrogen metabolites in tissues of . . . Content of estrone and estrogen metabolites in tissues of hysterocarcinoma, adenomyosis, and hysteromyoma tissue Senescence induction in human melanoma by the combined action of type II interferon and tumor necrosis factor Trypsin-like proteinases and tissue inhibitors in adenomyosis and endometrial cancer e22214
Role of Hormones in Common Benign Uterine Lesions: Endometrial . . . - PubMed Leiomyoma, adenomyosis, and endometrial polyps are benign uterine disorders which seem to develop in the context of hormonal imbalances, due to steroid hormones, estrogen and progesterone, in association with various factors ranging from genetic factors to modifiable lifestyle factors
Acute abdomen caused by spontaneous rupture of degenerative . . . Here, we report a case of pregnancy with hysteromyoma complicated with rupture and bleeding The diagnosis and treatment strategies for pregnancy complicated with hysteromyoma-related acute abdomen are also reviewed, with an aim to provide a reference for clinical practice
Clinicopathological features and prognostic factors for uterine myoma This study analyzed the pathological characteristics of patients with uterine myoma, which may help improve the accuracy of disease diagnosis Age, operation method, myoma type, myoma location, myoma numbers, and pelvic adhesion are risk factors affecting the prognosis of uterine myoma, and can provide a reference for clinical treatment
The modern view on etiology, pathogenesis and modes of treatment of . . . The article presents actual data concerning possible pathology and pathogenesis of hysteromyoma The various views and theories related to origin of this disease are presented The modern classifications of this pathology are expounded