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Preparation of a solid self-microemulsifying drug delivery . . . S-SMEDDS were successfully prepared by HME, and an HMPCAS matrix was able to avoid microemulsion reconstitution and retain drug release in pH 1 2 (12 97%–25 54%) Conversely, microemulsion reconstitution and drug release were gradual in pH 6 8 and complete for some formulations
Preparation of Solid Self-Nanoemulsifying Drug Delivery . . . The present study focused on a new formulation approach to improving the solubility of drugs with poor aqueous solubility A hot melt extrusion (HME) process was applied to prepare drug-loaded solid self-nanoemulsifying drug delivery systems
A Conceptual Analysis of Solid Self-emulsifying Drug Delivery . . . SSMEDDS are physically stable, easy to manufacture, easy to fill in gelatin capsules as well as improve the drug bioavailability by releasing the drug in the emulsion form into the gastrointestinal tract and enable smooth absorption of the drug through the intestinal lymphatic pathway
HME as Advanced Approach for Development of Solid Self . . . The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology’s promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized
Preparation and Pharmacokinetics Evaluation of Solid Self . . . The results suggested that S-SMEDDS was an effective oral solid dosage form, which can improve the solubility and oral bioavailability of poorly water-soluble drug osthole KEY WORDS: osthole; self-microemulsion; spherical crystallization technique; bioavailability
Development of self-microemulsifying drug delivery system and . . . Solid-SMEDDS may be considered as a better solid dosage form as solidified formulations are more ideal than liquid ones in terms of its stability These results suggest the potential use of SMEDDS and solid-SMEDDS to improve the dissolution and hence oral bioavailability of poorly water-soluble drugs like telmisartan through oral route
Preparation of Solid Self-Nanoemulsifying Drug Delivery . . . A hot melt extrusion (HME) process was applied to prepare drug-loaded solid self-nanoemulsifying drug delivery systems (S-SNEDDS) by co-extrusion of liquid SNEDDS (L-SNEDDS) and different polymeric carriers Experiments were performed with L-SNEDDS formulations containing celecoxib, efavirenz or fenofibrate as model drugs