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Nature丨迟洪波组首次揭示代谢可以控制辅助性T细胞的可塑性_生物探索 12月19日,Nature在线刊登了一则来自圣犹达儿童研究医院(St Jude Children's Research Hospital)的迟洪波博士团队的题为Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity的研究论文。
Metabolic heterogeneity underlies reciprocal fates of TH17 cell . . . Single-cell RNA sequencing and experimental validation reveal heterogeneity in fate-mapped TH17 cells, and a developmental arrest in the TH1 transdifferentiation trajectory upon loss of mTORC1 activity or metabolic perturbation