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Systemic Lupus Erythematosus - StatPearls - NCBI Bookshelf Several immunopathogenic pathways play a role in the development of SLE Hargraves described the lupus erythematosus (LE cell) in 1948 Several pathogenic autoantibodies have since been identified
The Pathogenesis of Systemic Lupus Erythematosus – An Update Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE
Systemic Lupus Erythematosus (SLE) - Medscape SLE is a chronic inflammatory disease that can affect almost any organ system, although it mainly involves the skin, joints, kidneys, blood cells, and nervous system Its presentation and course
Lupus Symptoms, Causes, Risk Factors | NIAMS Systemic lupus erythematosus (lupus) is a chronic (long-lasting) autoimmune disease that can affect many parts of the body Lupus occurs when the immune system, which normally helps protect the body from infection and disease, attacks its own tissues
Pathogenesis of systemic lupus erythematosus - PMC The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved Multiple genes contribute to disease susceptibility
Lupus - Symptoms causes - Mayo Clinic As an autoimmune disease, lupus occurs when your immune system attacks healthy tissue in your body It's likely that lupus results from a combination of your genetics and your environment
Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular . . . Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs A complex interaction of genetics, environment, and hormones leads to immune dysregulation and breakdown of tolerance to self-antigens, resulting in
Systemic lupus erythematosus: Epidemiology and pathogenesis While the underlying disease pathogenesis is incompletely understood, it involves the development of one or more autoantibodies with the subsequent production of immune complexes and may be related to a variety of genetic, hormonal, and environmental factors