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Neladalkib Shows Durable Responses in Heavily Pretreated ALK . . . Topline data from the ALKOVE-1 phase 1 2 clinical trial (NCT05384626) demonstrate neladalkib’s (NVL-655; Nuvalent) promise for treatment of patients with advanced ALK-positive non-small cell lung cancer (NSCLC) previously treated with tyrosine kinase inhibitors (TKI) The data showed an objective response rate (ORR) of 31% (95% CI: 26, 37), with an estimated durability of response of 64% and
Alectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer Platinum-based chemotherapy is the recommended adjuvant treatment for patients with resectable, ALK-positive non–small-cell lung cancer (NSCLC) Data on the efficacy and safety of adjuvant
FDA Approves Alectinib for ALK-Positive Lung Cancer Alectinib targets cancer cells that have specific changes, called rearrangements, in the ALK gene The drug has been shown to increase how long people with ALK-positive metastatic NSCLC live and has become a mainstay for treatment of people with this form of lung cancer
Nuvalent Announces Positive Topline Pivotal Data from ALKOVE . . . Neladalkib has received breakthrough therapy designation from the U S Food and Drug Administration (FDA) for the treatment of patients with locally advanced or metastatic ALK-positive non-small cell lung cancer (NSCLC) who have been previously treated with 2 or more ALK tyrosine kinase inhibitors and orphan drug designation for ALK-positive NSCLC
Treatment Options for ALK+ - ALK Positive Treatment Options While our tumors share the ALK fusion gene, no two are identical There are many other differences in the tumor that may need to be considered in therapy planning Once you’re diagnosed with ALK+ lung cancer, your oncologist will determine the stage of your lung cancer and consider other factors for personalizing your treatment
Nuvalent’s Neladalkib Delivers Pivotal ALKOVE-1 Data in ALK . . . Nuvalent, Inc , a clinical-stage biotech, has recently sent shockwaves through the oncology market by announcing positive topline pivotal data from its ALKOVE-1 trial These results strongly suggest that the investigational ALK-selective inhibitor, neladalkib, could become a new, crucial treatment option for patients battling advanced ALK-positive non-small cell lung cancer (NSCLC)
Real-world treatment sequencing and effectiveness of second . . . With multiple targeted therapies approved for anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC), it is increasingly important to understand outcomes with various sequences of next-generation ALK tyrosine kinase inhibitors (TKIs) We describe contemporary sequencing patterns and treatment effectiveness of first-line (1L) and second-line (2L) treatments in
Lorlatinib Versus Crizotinib in Patients With Advanced ALK . . . Lorlatinib improved progression-free survival (PFS) and intracranial activity versus crizotinib in patients with previously untreated, advanced, ALK -positive non–small cell lung cancer (NSCLC) in the phase III CROWN study Here, we report long-term outcomes from CROWN after 5 years of follow-up