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Contents | Science 389, 6755 COVER This illustration shows the interface of the kinase NEK7 (light blue) and the E3 ubiquitin ligase substrate receptor cereblon (teal) The interaction is facilitated by the small molecule MRT-3486 (orange) This molecular glue compound creates new features at the surface of cereblon that permit formation of the complex with NEK7, thus promoting ubiquitination and degradation of this
About Us - Science | AAAS Science has been at the center of important scientific discovery since its founding in 1880 Today, Science continues to publish the very best in research across the sciences, with articles that consistently rank among the most cited in the world In the last half century alone, Science published: The entire human genome for the first time, never-before seen images of the Martian surface, and
Latest News - Science | AAAS Developing lenacapavir, the drug newly approved to protect against HIV for six months in one shot, took basic science, sophisticated chemistry, and perseverance
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Massive DNA sequencing effort reveals how colonization shaped . . . - Science Now, the largest genomic study of the Brazilian population to date, published today in Science, is painting a clearer picture of how that diversity came to be—and how centuries of colonization, migration, and social dynamics have shaped Brazil’s biology and health
Contents | Science 388, 6749 Coherently controlling the motion of single atoms in optical tweezers would enable new applications in quantum information science To demonstrate this, we first prepared atoms in their motional ground state using a species-agnostic cooling mechanism
What does Trump’s call for ‘gold standard science’ really mean? From lobster fishing bans to school closings during the COVID-19 pandemic, the misuse of science by federal agencies and individual researchers has fueled the public’s growing distrust of science So says U S President Donald Trump in a new executive order designed to promote “gold standard science” through transparency, replication, and taking swift action to correct errors and punish