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THE SHIKIMATE PATHWAY - PubMed The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds In a sequence of seven metabolic steps, phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, the precursor of the aromatic amino acids and many aromatic secondary metabolites
Shikimate Pathway - an overview | ScienceDirect Topics The shikimate pathway enzymes employ erythrose-4-phosphate and phosphoenol pyruvate (primary metabolites) as substrates to initiate the aromatic building block synthesis In this pathway, the first seven enzymes catalyze the chemical reactions in a sequential manner to generate chorismate
Revisiting the shikimate pathway and highlighting their enzyme . . . By applying bioinformatics tools, thousands of enzyme inhibitors of this metabolic pathway can be prospected at a low cost and in a short time Here, we revisit how the enzymes of the shikimate pathway have been characterized and update the status of their inhibitors in microorganisms and plants
The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic . . . The shikimate pathway was discovered as the biosynthetic route to the aromatic amino acids phenylalanine, tyrosine, and tryptophan through the classic studies of Bernhard Davis and David Sprinson and their collaborators This pathway has been found only in microorganisms and plants
The shikimate pathway: gateway to metabolic diversity Seven metabolic steps convert phosphoenolpyruvate (PEP) and erythrose 4-phosphate (E4P) into shikimate and ultimately chorismate, which serves as the branch point for dedicated aromatic amino acid biosynthesis
The Biosynthetic Pathways for Shikimate and Aromatic Amino Acids in . . . The shikimate pathway, also known as the chorismate biosynthesis pathway, converts two metabolites, phosphoenolpyruvate (PEP) of the glycolysis pathway and erythrose 4-phosphate (E4-P) of the non-oxidative branch of the pentose phosphate pathway, into chorismate (Fig 2)
Shikimic Acid Pathway - an overview | ScienceDirect Topics Microbial production of shikimic acid involves the shikimic acid (or shikimate) pathway Shikimic acid pathway occurs commonly in microorganisms and therefore they can be used to overproduce this compound from carbon sources such as glucose (Draths et al , 1999; Simonart and Wiaux, 1960)