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Package Insert - ADSTILADRIN ADSTILADRIN is a non-replicating adenoviral vector-based gene therapy designed to deliver a copy of a gene encoding a human interferon-alfa 2b (IFNα2b) to the bladder urothelium
Nadofaragene firadenovec - Wikipedia Nadofaragene firadenovec, sold under the brand name Adstiladrin, is a gene therapy for the treatment of bladder cancer [1][3][4] It is a non-replicating (cannot multiply in human cells) adenoviral vector-based gene therapy
Adstiladrin: Uses, Dosage, Side Effects Warnings - Drugs. com Adstiladrin (nadofaragene firadenovec-vncg) is a gene therapy used to treat high-risk Bacillus CalmetteGuérin (BCG)-unresponsive non-muscle invasive bladder cancer Includes Adstiladrin side effects, interactions and indications
Nadofaragene firadenovec-vncg (urinary bladder route) Description Nadofaragene Firadenovec-vncg is used to treat patients with high-risk Bacillus Calmette-Guerin (BCG)-unresponsive, non-muscle invasive bladder cancer (NMIBC) with a tumor type called carcinoma in situ (CIS) with or without papillary tumors This medicine is to be used only by or under the direct supervision of a doctor
Mechanism of action of nadofaragene firadenovec-vncg - PMC Effective bladder-preserving therapeutic options are needed for patients with bacillus Calmette-Guérin unresponsive non–muscle-invasive bladder cancer Nadofaragene firadenovec-vncg (Adstiladrin®) was approved by the US Food and Drug Administration
Nadofaragene firadenovec-vncg (ADSTILADRIN) National Drug . . . Description Mechanism of Action • Nadofaragene firadenovec is a non-replicating adenoviral vector-based gene therapy for bladder instillation The replication-deficient adenovirus vector contains a transgene encoding the human interferon alfa-2b (IFNα2b) It delivers a copy of the gene encoding IFNα2b to the bladder urothelium resulting in local expression of the IFNα2b protein for anti
Nadofaragene Firadenovec-vncg - NCI - National Cancer Institute This page contains brief information about nadofaragene firadenovec-vncg and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials
Package Insert - ADSTILADRIN ADSTILADRIN is a non-replicating adenoviral vector-based gene therapy indicated for the treatment of adult patients with high-risk Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors
Real-World Analysis of Nadofaragene Firadenovec Use in BCG . . . Ashish Kamat speaks with Gabriela Díaz and Laura Bukavina about real-world utilization of nadofaragene firadenovec for BCG-unresponsive bladder cancer patients Using the TriNetX federated database platform, the team analyzed 205 patients across 28 institutions treated between 2022 and 2025