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NNK - Wikipedia NNK is a known mutagen, which means it causes polymorphisms in the human genome Studies showed that NNK induced gene polymorphisms in cells that involve in cell growth, proliferation and differentiation
Nicotine-Derived Nitrosamine Ketone - ScienceDirect Nicotine-derived nitrosamine ketone (NNK), or 4- (methylnitrosamino)-1- (3-pyridyl)-1-butanone, is a carcinogenic nitrosamine that is present in tobacco smoke and is activated by CYP2A3 6
Nicotine-Derived Nitrosamine Ketone (NNK) - Springer One of the main tobacco-specific nitrosamines generated from nicotine is nitrosamine ketone (4- (methylnitrosamino)-1- (3-pyridyl)-1-butanone, or NNK) It is significant for the development of cancer
update on the formation in tobacco, toxicity and carcinogenicity of Nʹ . . . New mechanistic insights are presented regarding the role of dissimilatory nitrate reductases in certain microorganisms involved in the conversion of nitrate to nitrite that leads to the formation of NNN and NNK during curing and processing of tobacco
NNK | Nicotine-nitrosated Derivative | MedChemExpress NNK is a nicotine-nitrosated derivative NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1 2 and PKCα
NNK - Wikiwand NNK is known as a mutagen, which means it causes polymorphisms in the human genome Studies showed that NNK induced gene polymorphisms in cells that involve in cell growth, proliferation and differentiation
NNK – Knowledge and References – Taylor Francis NNK is a tobacco-specific carcinogen that contributes to lung cancer development It induces a high percentage of lung tumors in males and a significant yield of lung tumors in females, including squamous cell carcinomas
NNK | ERK1 2 Activator | PKCα Activator | TargetMol NNK is a nitrosated derivative of nicotine that activates the ERK1 2 and PKCα signaling pathways, induces Bcl2 phosphorylation at Ser70, and activates c-Myc at Thr58 and Ser62, thereby promoting the proliferation and survival of human lung cancer cells, and is commonly used to establish lung cancer mouse models