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ALK and Lung Cancer - American Lung Association ALK stands for anaplastic lymphoma kinase It was originally described in lymphoma, but most ALK-positive cancers are in non-small cell lung cancer
Targeting ALK Rearrangements in NSCLC: Current State of the Art ALK signaling is activated in cancer cells primarily through three mechanisms: gene fusions, gene amplification, and activating point mutations (2) ALK rearrangements were first identified in 2007 in NSCLC, where the 3′ region of the ALK gene was fused with the 5′ sequence of the echinoderm microtubule-associated protein-like 4 (EML4) gene
Lorbrena Effective as Initial Treatment of ALK-Positive NSCLC The findings are the latest from the CROWN study Participants were randomly assigned to receive either lorlatinib or crizotinib as a treatment for advanced lung tumors with ALK gene mutations, a disease called ALK-positive lung cancer
ALK-Positive Lung Cancer: Symptoms, Treatment, and Prognosis The mutation is a gene rearrangement: an abnormal fusion of ALK and another gene, echinoderm microtubule-associated protein-like 4 (EML4) 1 This fusion causes cell enzymes (specialized proteins) to send signals to mutated cancer cells instructing them to divide and multiply more quickly than usual The result: the spread of lung cancer
ALK-Positive Lung Cancer: Diagnosis, Treatment, and Outlook ALK-positive lung cancer is a distinct molecular subtype of non-small cell lung cancer (NSCLC) This diagnosis is defined by a specific genetic alteration within the cancer cells, rather than by the location or appearance of the tumor
Treatment Options for ALK+ - ALK Positive Treatment Options While our tumors share the ALK fusion gene, no two are identical There are many other differences in the tumor that may need to be considered in therapy planning Once you’re diagnosed with ALK+ lung cancer, your oncologist will determine the stage of your lung cancer and consider other factors for personalizing your treatment
Personalized approaches to lung cancer treatment: A review of targeted . . . Globally, lung cancer—more specifically, non-small cell lung cancer (NSCLC)—contributes significantly to the death toll from cancer Recent advances in molecular research have identified key genetic mutations that drive tumor growth, including those in the EGFR, KRAS, ALK, and MET genes, accounting for around 80 % of lung cancers that are categorized as non-small cell lung cancer (NSCLC