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Gene - TNFSF11 Secreted by osteoblasts and stromal cells, TNFSF11 binds to its receptor RANK on osteoclast precursors to stimulate their differentiation, activation, and survival, a process essential for both normal skeletal maintenance and pathological bone resorption
TNFSF11: The Key Regulator of Bone Metabolism and Immune Function Explore TNFSF11, a crucial gene involved in bone remodeling, immune system regulation, and various diseases Learn about its roles in osteoclastogenesis, lymphocyte activation, and cancer development
What are TNFSF11 agonists and how do they work? - Patsnap TNFSF11 agonists have shown promise in several therapeutic areas, particularly in bone diseases and cancer In the context of bone health, these agonists can be used to treat conditions characterized by inadequate bone formation or excessive bone loss, such as osteoporosis and osteopetrosis