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Microneedles for delivery of anticancer therapeutics: recent . . . - Springer Implementation of microneedles (MNs) as a therapeutic delivery vehicle has revolutionized anticancer therapy, thanks to MNs’ minimally invasive and painless delivery aspect, high therapeutic efficacy, low cost, and relative biosafety
Progress and perspective of microneedle system for anti-cancer drug . . . This combined therapy showed excellent anticancer effect than either PTT or chemotherapy only and found to cure without relapse Chen et al also made several advancements in transdermal drug delivery through MNs, especially for anti-cancer PTT [32, 90, 91]
Micro-syringe chip-guided intratumoral administration of lipid . . . The MSC-guided administration of LNPs greatly enhances the therapeutic efficiency of anticancer drugs via the slow diffusion mechanism through micro-syringe to tumor tissues for 6 h, whereas they bypass most hurdles of systemic delivery including hepatic metabolism, rapid renal clearance, and intera …
The curative effect analysis of peripherally inserted central venous . . . The new type of medical guide wire assembly combined with mobile phone app has definite beneficial effect and accurate positioning Patients can get higher success rate of one-time catheterization and success rate of catheterization, while the incidence of complications of patients is reduced
Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent . . . Both the delivery systems (MNs and penetration enhancers) were found to be promising and progressive in delivering honokiol through the layers of skin Additionally, the anti-cancer effect of honokiol was evident with decreased release of cytokine interleukin-6 and suppression of Ki-67 protein
Microneedle-based delivery devices for cancer therapy: A review Based on the promising results demonstrated by the microneedle systems in the local administration of anticancer therapeutics, this review summarizes the different microneedle formulations developed up to now aimed for application on cancer therapy (mphasizing those produced with polymers)
Modeling multi-needle injection into solid tumor - PubMed However, as of today, the anticipated curative effect of anti-CTLA-4 and PD-1 PD-L1 mAb treatments has been observed only in a small population of patients In addition, systemic administration of mAbs in clinics has been found associated with new toxicity profiles, sometimes very severe
Adoptive cell therapy with macrophage-drug conjugates facilitates . . . A curative effect in this model was confirmed by MRI in selected animals To assess long-term tumor immunity, these long-term survivors were rechallenged 6 months later with implantation of CT-2A cells in the opposite hemisphere of the brain, and they resisted tumor growth, suggesting that MDC-735 not only eliminated tumors but also induced a