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Glucokinase activators (GKAs) promise a new pharmacotherapy . . . Chemical structures of glucokinase activators used in extensive preclinical studies using (a) RO-0274375-000 (Cpd A) or (b) RO-0281675-000 (Cpd R) and short-term phase II trials in type 2 diabetes mellitus with (c) RO-4389620-000 (piragliatin) [1-6,8-10]
Glucokinase Activators for Diabetes Therapy Selection of new drug targets to treat type 2 diabetes has to be guided primarily by consideration of established physiological chemistry of glucose homeostasis and of prevailing views about the pathophysiology of type 2 diabetes because the genetics of the disease that could serve as another guiding principle remain prohibitively perplexing
GKA - Definition by AcronymFinder Rank Abbr Meaning; GKA: Goroka, Papua New Guinea - Goroka (Airport Code) GKA: Group Key Agreement (computer security) GKA: Global Key Account: GKA: Global Kids Academy (Japan)
Medicine - LWW cose in patients with type 2 diabetes We compared the efficacy safety of glucokinase activators in T2DM patients through a meta-analysis Methods: We searched PubMed, Excerpt Medica Database, and Cochrane Central Register of Controlled Trials databases for articles published before December 30, 2020 Two independent reviewers extracted the information from article The quality of articles