GABIONS MACCAFERRI DU CANADA LTEEBusiness Directories,Company Directories

Company Name: Corporate Name:	GABIONS MACCAFERRI DU CANADA LTEE
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Company Address:	1177 Autoroute 440 Laval O,CHOMEDEY,QC,Canada
ZIP Code: Postal Code:	H7S
Telephone Number:	4506299149
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USA SIC Code(Standard Industrial Classification Code):	0
USA SIC Description:	OFFICE FURNITURE & EQUIP NEW
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Lipid Nanoparticle Delivery System for mRNA Encoding B7H3 . . . - PubMed
The therapeutic use of bispecific T-cell engaging (BiTE) antibodies has shown great potential for treating malignancies BiTE can simultaneously engage CD3ε on T cells and tumor antigen on cancer cells, thus exerting an effective antitumor effect
Elimination of large tumors in mice by mRNA-encoded bispecific . . .
We circumvented these limitations by treating mice with in vitro –transcribed pharmacologically optimized, nucleoside-modified mRNA encoding the antibody We achieved sustained endogenous
A multiscale physiologically based pharmacokinetic model to support . . .
mRNA-encoded BiTEs are a rather recent technology, warranting further investigation in determining optimal doses and dosing schedules, as well as elucidating the intricate processes governing mRNA and antibody traficking
Recent Advances in Site-Specific Lipid Nanoparticles for mRNA Delivery
In another study, Huang et al use a novel LNP to deliver mRNA encoded with bispecific T-cell engaging (BiTE) antibody B7H3-CD3, which could bind with B7H3 receptors on tumor cells and CD3 receptors on T cells simultaneously, thereby inducing the recognition of tumor cells by T cells and antitumor efficacy 63 The LNP was composed of DMG-PEG
BiTE secretion from in situ-programmed myeloid cells results in tumor . . .
We demonstrate that a BiTE-encoding mRNA nanodrug enables preferential permeation of the BiTE into tumor tissue, making the therapy more efficacious and safer compared to conventional infusions of BiTE antibodies
Lipid Nanoparticle Delivery System for mRNA Encoding B7H3â redirected . . .
Here, we show that a novel and liver-targeted ionizable lipid nanoparticle delivery system for mRNA encoding B7H3×CD3 BiTE exerts potent antitumor activity against hematologic and solid tumors compared with purified recombinant BiTE
1358 Tissue-targeted lipid nanoparticle delivery for mRNA encoding . . .
However, the relatively short serum half-life of recombinant BiTE, and reported CRS and neurotoxicity have limited its applications Here, we describe tissue targeted LNP-mRNA encoding BiTE that expressed long-lasting and therapeutic levels of BiTE protein at the tar-geted tumor sites
BiTE secretion from in situ-programmed myeloid cells results . . . - PubMed
To address these challenges, we developed targeted nanocarriers that can deliver in vitro-transcribed mRNA encoding BiTEs to host myeloid cells - a cell type that is actively recruited into the tumor microenvironment
GitHub - cosbi-research PBPKmRNABiTE: A multi-scale physiologically . . .
SCM_simulation m: Source code for the model simulation for both recombinant and mRNA-encoded protein administration in the Short Chain Model Fixing the dose injected and the observation time window allows computing the time evolution of BiTEs' concentration in blood
1358 Tissue-targeted lipid nanoparticle delivery for mRNA encoding . . .
Here, we describe tissue targeted LNP-mRNA encoding BiTE that expressed long-lasting and therapeutic levels of BiTE protein at the targeted tumor sites