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The Search for New Anticonvulsants in a Group of (2,5 . . . We applied an optimized coupling reaction yielding several hybrid compounds that showed broad-spectrum activity in widely accepted animal seizure models, namely, the maximal electroshock (MES) test and the psychomotor 6 Hz (32 mA) seizure model in mice
2,5-Dioxopyrrolidin-1-yl 4-nitrobenzoate | C11H8N2O6 | CID . . . 2,5-Dioxopyrrolidin-1-yl 4-nitrobenzoate | C11H8N2O6 | CID 2180606 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety hazards toxicity information, supplier lists, and more
Design, synthesis and anticonvulsant activity of new hybrid . . . In the current studies, a focused library of 21 N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)propanamides, 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)propanamides, and 2-(2,5-dioxopyrrolidin-1-yl)butanamides as potential new hybrid anticonvulsant agents was synthesized
New hybrid molecules with anticonvulsant and antinociceptive . . . Compounds 5-38 were prepared in a coupling reaction of the 3-methyl- or 3,3-dimethyl-2-(2,5-dioxopyrrolidin-1-yl)propanoic (1, 2) or butanoic acids (3, 4) with the appropriately substituted secondary amines in the presence of the N,N-carbonyldiimidazole reagent
The Search for New Anticonvulsants in a Group of (2,5 . . . - MDPI The previous studies in series of 2-(2,5-dioxopyrrolidin-1-yl)propanamides, represented by compounds AS-1 and DK-1 (see Figure 1), showed that these molecules interact with voltage-gated sodium channels and Cav 1 2 (L-type) calcium channels at very high concentrations of 100 µM or 500 µM
Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl . . . The present chemical and pharmacological studies confirmed favorable absolute configuration for the optimal antiseizure activity of racemates identified in a group of N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamides reported previously