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Acute chronic active T cell mediated rejection Acute T cell mediated rejection (TCMR): Usually seen during the first month after transplantation or later as immune suppression decreases due to noncompliance, adjustment of medication by physicians (as complications present), gastrointestinal diseases, metabolic diseases, etc Presents with acute renal failure or oliguria; may also be asymptomatic (diagnosed on protocol biopsies) Chronic
Active chronic active antibody mediated rejection Kidney nontumor - Active chronic active antibody mediated rejection Alloimmune reaction to donor specific antigens resulting in damage to the kidney allograft
Pathology Outlines - Antibody mediated rejection Antibody mediated rejection (AMR) is a form of allograft rejection characterized by the presence of donor specific antibodies (DSA) directed against human leukocyte antigens (HLA) on the donor endothelium
Pathology Outlines - Recurrent disease Recurrent disease: chronic liver disease can lead to a patient needing liver transplantation (LT); some of these chronic diseases can recur following LT
Pathology Outlines - Question Bank A biopsy showed moderate T cell mediated rejection (TCMR) and the patient received steroids with no significant improvement Assessment of pretransplant workup showed that the patient is sensitized and had a positive crossmatch Posttransplant workup showed persistent Donor specific antibodies (multiple specificities, sum MFI 36,928)
Pathology Outlines - Question Bank A 20 year old man with known cystic fibrosis presents with abdominal pain localized to the right lower quadrant Imaging reveals an enlarged, mucus filled appendix What is the most likely histologic finding in the appendix of this patient? Appendiceal dilation with inspissated mucus Epithelial dysplasia with fibrotic changes Hyperplasia of the lymphoid tissue Mucinous neoplasms