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Rituximab for Multiple Sclerosis: Hiding in Plain Sight - PMC Most insurance carriers in the United States and Europe limited access to rituximab for MS, citing lack of regulatory approval Kaiser Permanente and Sweden, however, authorized use, enabling evidence to satisfy FDA criteria for drug approval to be generated
Infusion Therapy Plan Orders | Kaiser Permanente Washington • Biosimilar riTUXimab-arrx is the preferred and defaulted agent in this plan • Standard Dosing: Administered as 2 doses of 500-1000 mg, two weeks apart (Day 1 and Day 15) • Weekly Dosing: Administered at 375 mg m2 once weekly for 4 weeks
CRITERIA FOR DRUG COVERAGE - Kaiser Permanente the prescription drug benefit for 12 months when the following criteria are met: • Prescribed by a Neurologist with expertise in Multiple Sclerosis • Diagnosis of Relapsing form of Multiple Sclerosis (MS), including:
Indications for Rituximab Use in an Integrated Health Care . . . Factors associated with rituximab use for an FDA-approved indication included increased age (adjusted odds ratio [AOR] = 1 05, 95% CI = 1 04-1 07) and increased burden of chronic disease (chronic disease score: AOR = 1 07, 95% CI = 1 02-1 12; Charlson Comorbidity Index score: AOR = 3 52, 95% CI = 3 03-4 10)
RITUXIMAB WILL BE APPROVED IF THE FOLLOWING PRIOR . . . • Rituximab is being prescribed at an FDA approved dose If all of the above conditions are met, the request will be approved for up to a 1 year duration; if all of the above criteria are not met, the request is referred to a Medical Director clinical
Rituximab for Multiple Sclerosis - Neurology Most insurance carriers in the United States and Europe limited access to rituximab for MS, citing lack of regulatory approval Kaiser Permanente and Sweden, however, authorized use, enabling evidence to satisfy FDA criteria for drug approval to be generated
Rituximab (Riabni®, Rituxan®, Ruxience®, Truxima®) Truxima (rituximab-abbs) and Ruxience (rituximab-pvvr) are the preferred rituximab products Coverage will be provided for Truxima and Ruxience contingent on the coverage criteria in the Diagnosis-Specific Criteria section