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A national study of plasma use in critical care: clinical indications . . . Introduction Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of plasma use in critical care We carried out a multicentre study of coagulopathy in intensive care units (ICUs) and here describe overall FFP utilisation in adult critical care, the indications for transfusions, factors indicating the doses used and the effects of FFP use on coagulation Methods We
Balanced massive transfusion ratios in multiple injury patients with . . . Introduction Retrospective studies have demonstrated a potential survival benefit from transfusion strategies using an early and more balanced ratio between fresh frozen plasma (FFP) concentration and packed red blood cell (pRBC) transfusions in patients with acute traumatic coagulopathy requiring massive transfusions These results have mostly been derived from non-head-injured patients The
Therapeutic target of high fresh frozen plasma to red blood cell ratio . . . To assess heterogeneous treatment effects of high fresh frozen plasma (FFP) to red blood cell (RBC) transfusion ratios in patients with severe blunt trauma and to identify subgroups that derive the greatest survival benefit This multicenter retrospective cohort study used data from the Japan Trauma Data Bank (2019–2023)
Pre-hospital plasma transfusion: a valuable coagulation support or an . . . Moreover, the INR of FFP is 1 3 [6] Any beneficial effect of plasma to correct slightly elevated INR is futile and plasma has primarily an effect on coagulation parameters with extended volumes and performs best in patients bleeding and coagulopathic
Guideline-concordant administration of prothrombin complex concentrate . . . FFP: Fresh frozen plasma GC-PCC-K: Guideline-concordant of administration PCC and Vitamin K GCS: Glasgow coma scale score HR: Hazard ratio ICH: intracranial hemorrhage INR: International normalized ratio OR: Odds ratio PCC: Prothombin concentrated complex SAP: Systolic arterial blood pressure VKA: Vitamin K antagonist
Evaluation of the implementation of a massive transfusion protocol . . . A massive transfusion protocol (MTP) aims to provide standardized and early delivery of blood products and prohemostatic agents by keeping pre-thawed fresh frozen plasma (FFP) available Implementation of MTP is assumed to result in transfusion with higher ratios of FFPs and platelets to red blood cells (RBCs) Pre-thawing may also result in waste of FFPs These MTP benefits or disadvantages
The effect of male-donor-only fresh frozen plasma on the incidence of . . . In July 2003 the English Blood Service stopped using female donor plasma for the manufacture of fresh frozen plasma (FFP) Patients undergoing repair of ruptured abdominal aortic aneurysm (AAA) receive large amounts of FFP and often develop ALI
The efficacy and safety of plasma exchange in patients with sepsis and . . . Introduction Sepsis and septic shock are leading causes of intensive care unit (ICU) mortality They are characterized by excessive inflammation, upregulation of procoagulant proteins and depletion of natural anticoagulants Plasma exchange has the potential to improve survival in sepsis by removing inflammatory cytokines and restoring deficient plasma proteins The objective of this study is
Definitions of massive transfusion in adults with critical bleeding: a . . . Background Definitions for massive transfusion (MT) vary widely between studies, contributing to challenges in interpretation of research findings and practice evaluation In this first systematic review, we aimed to identify all MT definitions used in randomised controlled trials (RCTs) to date to inform the development of consensus definitions for MT Methods We systematically searched the
Detection of hypovolemia by non-invasive hemodynamic monitoring during . . . Background Fluid loading with crystalloids is the conventional treatment of major hemorrhage but might tend to create fluid overload We studied hemodynamic profiles of fluid replacement therapies during major surgical hemorrhage and compared the ability of pulse pressure variation (PPV), plethysmographic variation index (PVI), cardiac output (CO) and Guyton´s approach to detect hypovolemia