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Clinical review: Fresh frozen plasma in massive bleedings - more . . . Fresh frozen plasma (FFP) is indicated for the management of massive bleedings Recent audits suggest physician knowledge of FFP is inadequate and half of the FFP transfused in critical care is inappropriate Trauma is among the largest consumers of FFP Current trauma resuscitation guidelines recommend FFP to correct coagulopathy only after diagnosed by laboratory tests, often when overt
Effect of early administration of fibrinogen replacement therapy in . . . Background In severely injured trauma patients, hypofibrinoginaemia is associated with increased mortality There is no evidence-based consensus for what constitutes optimal fibrinogen therapy, treatment dose or timing of administration The aim of this systematic review was to evaluate the effects of early fibrinogen replacement, either cryoprecipitate or fibrinogen concentrate (FgC) on
Clinical effectiveness of fresh frozen plasma compared with fibrinogen . . . Introduction Haemostatic therapy in surgical and or massive trauma patients typically involves transfusion of fresh frozen plasma (FFP) Purified human fibrinogen concentrate may offer an alternative to FFP in some instances In this systematic review, we investigated the current evidence for the use of FFP and fibrinogen concentrate in the perioperative or massive trauma setting Methods
Effect of transfusion of fresh frozen plasma on parameters of . . . Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage Adverse effects of FFP have been well described, including acute lung injury However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion Furthermore, FFP has an endothelial
A national study of plasma use in critical care: clinical indications . . . Introduction Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of plasma use in critical care We carried out a multicentre study of coagulopathy in intensive care units (ICUs) and here describe overall FFP utilisation in adult critical care, the indications for transfusions, factors indicating the doses used and the effects of FFP use on coagulation Methods We
Prothrombin complex concentrate (PCC) for treatment of trauma-induced . . . Background Trauma-induced coagulopathy (TIC) is common in trauma patients with major hemorrhage Prothrombin complex concentrate (PCC) is used as a potential treatment for the correction of TIC, but the efficacy, timing, and evidence to support its use in injured patients with hemorrhage are unclear Methods A systematic search of published studies was performed on MEDLINE and EMBASE databases
Effect of therapeutic plasma exchange on antimicrobials in critically . . . Therapeutic plasma exchange (TPE) is a procedure in which plasma is separated from the cellular components of whole blood by various methods The removed plasma is replaced with albumin or fresh frozen plasma (FFP) TPE aims to eliminate disease-related pathogens [1] Removal of significant amounts of plasma during TPE can alter the pharmacokinetic profiles of antimicrobials, resulting in
Therapeutic target of high fresh frozen plasma to red blood cell ratio . . . To assess heterogeneous treatment effects of high fresh frozen plasma (FFP) to red blood cell (RBC) transfusion ratios in patients with severe blunt trauma and to identify subgroups that derive the greatest survival benefit This multicenter retrospective cohort study used data from the Japan Trauma Data Bank (2019–2023)
Balanced massive transfusion ratios in multiple injury patients with . . . Introduction Retrospective studies have demonstrated a potential survival benefit from transfusion strategies using an early and more balanced ratio between fresh frozen plasma (FFP) concentration and packed red blood cell (pRBC) transfusions in patients with acute traumatic coagulopathy requiring massive transfusions These results have mostly been derived from non-head-injured patients The
Clinical review: Prothrombin complex concentrates - evaluation of . . . The aims of the present review are to provide a systematic overview of thrombotic complications reported with PCCs, to examine the possible pathogenesis of thrombotic events, and to discuss safety precautions and means to reduce thrombotic complications Furthermore, the review performs a critical comparison of PCC with FFP