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LGALS3BP galectin 3 binding protein [ (human)] LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV) It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity
Extracellular LGALS3BP: a potential disease marker and actionable . . . In this work, we demonstrated that vesicular galectin‐3‐binding protein (LGALS3BP), a glycosylated protein overexpressed in a variety of human malignancies, is a potential GBM disease marker and can be efficiently targeted by a specific antibody–drug conjugate (ADC)
Lectin Galactoside-binding Soluble 3 Binding Protein (LGALS3BP) Is a . . . Here we used affinity chromatography of tumor cell extracts to identify LGALS3BP as a novel sialic acid-dependent ligand for human Siglec-9 and for other immunomodulatory Siglecs, such as Siglec-5 and Siglec-10 In contrast, the mouse homolog Siglec-E binds to murine LGALS3BP with lower affinity
Role of galectin 3 binding protein in cancer progression: a potential . . . The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells It was first identified as cancer and metastasis associated protein, while its role in innate
LGALS3BP antibody-drug conjugate enhances tumor-infiltrating . . . Our findings establish that circulating LGALS3BP is a potential biomarker for liquid biopsy and uncover this protein as a suitable target for therapeutic strategies combining 1959-sss DM4 ADC with an anti-PD-1 ICI for the treatment of LGALS3BP expressing neuroblastoma