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Testing for Tuberculosis: Blood Test | Tuberculosis (TB) | CDC TB blood test TB blood tests (also called interferon-gamma release assays or IGRAs) use a blood sample to find out if you are infected with TB germs The tests measure how your immune system reacts when a small amount of your blood is mixed with TB proteins Your health care provider will use one of the two TB blood tests approved for use in the United States: QuantiFERON®-TB Gold Plus (QFT
Clinical Testing Guidance for Tuberculosis: Interferon Gamma Release . . . Background About the TB blood test The TB blood test (interferon gamma release assay [IGRA]) mixes a patient’s blood samples with peptides that simulate antigens derived from TB bacteria and with controls The TB antigens were chosen because they are found in M tuberculosis complex, including M bovis, but they are absent from BCG and from the majority of other mycobacteria In most people
Guidelines for Using the QuantiFERON However, in 2001, a new test (QuantiFERON®-TB or QFT; manufactured by Cellestis Limited, Carnegie, Victoria, Australia) that measures the release of interferon-gamma in whole blood in response to stimulation by purified protein derivative was approved by the Food and Drug Administration
Clinical Testing and Diagnosis for Tuberculosis Clinical Testing and Diagnosis for Tuberculosis Key points CDC recommends testing people who are at increased risk for TB infection People with symptoms of TB disease or positive TB blood test or TB skin results should be evaluated for TB disease TB testing activities should be accompanied by a plan for medical evaluation and treatment
Guidelines for Using the QuantiFERON lt;SUP gt;® lt; SUP gt;-TB Gold Test for . . . The blood must be incubated with the test antigens <12 hours after collection, while the lymphocytes are viable After the blood is incubated with antigens for 16--24 hours, plasma must be collected and either properly stored or tested promptly by ELISA
ICD-10-CM Codes for Tuberculosis | Tuberculosis (TB) | CDC Health care providers can use International Classification of Diseases, Clinical Modification (ICD-CM) codes to distinguish between initial testing for latent tuberculosis (TB) infection and evaluation screening for TB disease in medical records
Frequency of Tuberculosis Screening and Testing for Health Care . . . Health care personnel with a previous negative TB test result should be tested immediately and re-tested 8 to 10 weeks after the last known exposure For consistency, use the same type of TB test (e g , TB blood test or TB skin test) that was used upon hire (i e , preplacement) and for any follow-up testing
Testing for Tuberculosis | Tuberculosis (TB) | CDC Testing for Tuberculosis Key points There are two types of tests for tuberculosis (TB) infection: the TB blood test and the TB skin test A positive test result for TB infection means you have TB germs in your body
TB 101 - TB Blood Tests (Interferon-Gamma Release Assays [IGRA]) (1 2 . . . Interferon-gamma release assays (IGRAs) are TB blood tests that measure a person’s immune reactivity to M tuberculosis There are two TB blood tests available in the United States: QuantiFERON®-TB Gold Plus (QFT-Plus) T-SPOT® TB (T-Spot) *Use of trade names and commercial sources is for identification only and does not imply endorsement by the U S Department of Health and Human Services
Bacille Calmette-Guérin (BCG) Vaccine for Tuberculosis BCG Vaccine and TB Testing The BCG vaccine may cause a false-positive TB skin test reaction There is no reliable way to distinguish a positive TB skin test reaction caused by BCG vaccination from a reaction caused by true TB infection TB blood tests (interferon-gamma release assay or IGRA) are the preferred test for people who have received the BCG vaccine, including children BCG