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New guideline provides treatment recommendations for RLS The use of low-dose, extended-release oxycodone and other low-dose opioids also received conditional recommendations of support The authors noted that low-dose opioids have demonstrated efficacy for RLS, but opioids also have risks that require cautious use and clinical oversight
Opioids for restless legs syndrome - PMC Restless legs syndrome (RLS) is a very common neurological disorder in which patients complain of an intense need to move their legs, and unpleasant sensations felt deep in their legs, all occurring while at rest, mostly at bedtime
Guidelines for safe use of opioids to treat RLS -FINAL “The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome,” offers guidance to clinicians on safe and proper prescribing of opioids for RLS, how to assess patients for risk of addiction, and how to monitor opioid use over time
The Appropriate Use of Opioids in the Treatment of Refractory . . . Controlled-release medication should be used for evening dosage and short-acting drugs, if needed, during the day Effective doses are considerably lower than used for chronic pain (oxycodone 10-30 mg daily; methadone 5-20 mg daily) and the risk of opioid use disorder is relatively low
Opioids to Treat Restless Legs Syndrome Opioids should not be prescribed to people with RLS who also have untreated or undertreated sleep apnea Opioids can make obstructive sleep apnea worse or induce central sleep apnea
New Treatment Guidelines For Restless Legs Syndrome (RLS) Low dose opioids can be a safe and effective treatment for RLS The most commonly prescribed opioid for RLS is a very low dose of methadone (i e , one-tenth of what is used for chronic pain) It doesn’t give the “high” of many opioids and thus carries a lower risk of being abused by RLS patients
Practice Guideline: Treatment of Restless Legs Syndrome in Adults This is a summary of the American Academy of Neurology (AAN) guideline, “Treatment of restless legs syndrome in adults,” which was published in Neurology® online on November 16, 2016, and appears in the December 13, 2016, print issue
Opioid Treatment for Restless Legs Syndrome Outcomes . . . Opioids are a consensus second-line treatment for moderate to severe restless legs syndrome (RLS) The use of buprenorphine in RLS can facilitate successful weaning from dopamine agonists for patients with augmentation
Opioids and restless legs syndrome: a double-edged sword Those with withdrawal-related RLS had nearly double the opioid doses at admission to the program than those without such emergent symptoms, and morphine milligram equivalents > 20 at admission was a strong predictor of such symptoms