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Hematopoietic stem cells from pluripotent stem cells . . . Abstract The generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs) is an active and promising area of research; however, generating engraftable HSCs remains a major obstacle Ex vivo HSC derivation from renewable sources such as iPSCs offers an experimental tool for studying developmental hematopoiesis, disease modeling, and drug discovery, and yields
What is the Difference Between Pluripotent and Hematopoietic . . . Induced pluripotent stem cells (iPSCs) are generated by reprogramming adult cells, typically skin fibroblasts or blood cells, to a pluripotent state This reprogramming is achieved by introducing a set of specific transcription factors into the cells
Generating hematopoietic cells from human pluripotent stem . . . Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the production of blood cells for clinical application In two decades, almost all types of blood cells can be successfully generated from hPSCs through various differentiated strategies Meanwhile, with a deeper unde …
Hematopoiesis from Pluripotent Stem Cells | GeneGlobe Hematopoiesis from Pluripotent Stem Cells Hematopoietic Stem Cells (HSC) have the property of self-renewal, and through cell division and differentiation, form populations of progenitor cells which are committed to the main marrow cell lineages, including erythroid, granulocytic, monocytic, megakaryocytic and lymphocytic lineages
Hematopoietic stem cells meet induced pluripotent stem cells . . . Hematopoietic stem cells (HSCs), the source of the entire blood cells repertoire, represent the first stem cells identified in an adult tissue, the bone marrow, and the first stem cells used as a therapy in humans, through bone marrow transplantation 1 Although this therapeutic approach is well established and used to treat a variety of hematological conditions, including leukemia, several