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Ibrutinib improves diffuse large B-cell lymphoma survival NCI researchers have found that adding the targeted therapy ibrutinib (Imbruvica) to standard chemotherapy can improve how long some younger people with a specific form of diffuse large B-cell lymphoma live The new findings come from a new analysis of a previously conducted phase 3 clinical trial called Phoenix
CLL and SLL Treatment | IMBRUVICA® (ibrutinib) The most common side effects of IMBRUVICA® in adults with B-cell malignancies (CLL SLL and WM) include low platelet count; diarrhea; tiredness; muscle, bone, and joint pain; low white blood cell count; rash; low red blood cell count (anemia); bruising; and nausea
Imbruvica (Ibrutinib) | Lymphoma News Today A total of 56 patients with various types of B-cell NHL were enrolled in the study The results showed that Imbruvica was well-tolerated across various types of B-cell NHL The FDA approved Imbruvica in 2013 for the treatment of patients with MCL based on the results of an open-label Phase 2 trial (NCT01236391) During the trial, 111 patients
Ibrutinib in Patients with Relapsed or Refractory Diffuse . . . Based on gene profiling, DLBCL can be further classified as activated B-cell-like lymphoma (ABC), germinal center B-cell-like lymphoma (GCB) and primary mediastinal B-cell lymphoma Most patients of DLBCL achieve complete remission (CR) after treatment with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone), which is
IMBRUVICA® (ibrutinib) receives positive CHMP opinion for the . . . TRIANGLE (NCT02858258) is an ongoing, European, randomised, open-label, Phase 3 investigator initiated study (IIS) led by the European MCL Network 2,3 It compared three treatment arms: ibrutinib combined with standard induction immunochemotherapy with or without autologous stem cell transplantation (ASCT) followed by 2-year fixed-duration
Ibrutinib improves survival for younger people with diffuse . . . “This new analysis provides a compelling rationale for doctors to consider adding ibrutinib to standard chemotherapy for the initial treatment of younger patients with non-GCB DLBCL,” said Wyndham H Wilson, M D , Ph D , senior investigator in the Lymphoid Malignancies Branch and a co-author of the study DLBCL is the most common type of
Ibrutinib as first-line therapy for mantle cell lymphoma: a . . . Advanced stage mantle cell lymphoma (MCL) is an incurable B-cell malignancy with a wide spectrum of clinical presentations and management approaches spanning active surveillance for asymptomatic and clinically indolent disease to urgent immunochemotherapy for aggressive variants 1 Selected fitter patients can achieve long remissions after intensive cytarabine- and rituximab-containing
U. S. FDA Approves IMBRUVICA® (ibrutinib) as First Treatment . . . Marginal zone lymphoma (MZL) is a slow-growing B-cell lymphoma arising from white blood cells (lymphocytes) at the edges of lymphoid tissue 3 MZL accounts for approximately 8% of all cases of non-Hodgkin's lymphoma in adults, and the median age of diagnosis is 65 years old 3,4 There are three sub-types of MZL: mucosa-associated lymphoid
[Ibrutinib: A new drug of B-cell malignancies] - PubMed Ibrutinib (Imbruvica®) is a first-in-class, orally administered once-daily, that inhibits B-cell antigen receptor signaling downstream of Bruton's tyrosine kinase (BTK) Ibrutinib has been approved in USA in February 2014 and in France in October 2014 for the treatment of patients with relapsed refr …