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Venetoclax combined with decitabine or azacitidine in treatment-naive . . . Venetoclax plus decitabine or azacitidine showed tolerable safety and favorable overall response rate (CR + CRi rate: 67%) in elderly patients with AML This novel combination regimen produced favorable responses in high-risk groups, such as age 75 or older, poor cytogenetics, and secondary AML
Ten-day Decitabine with Venetoclax in Acute Myeloid Leukemia: A Single . . . Abstract Background: Venetoclax with hypomethylating agents is a new standard of care for newly diagnosed (ND) patients with acute myeloid leukemia (AML) who are 75 years or older, or unfit for intensive chemotherapy Pharmacodynamic studies have suggested superiority of the longer 10-day regimen of decitabine which has shown promising results in high-risk AML in phase 2 trials We
ULKAMLAVEN_Protocol - BC Cancer BC Cancer Protocol Summary for Therapy of Acute Myeloid Leukemia using azaCITIDine and Venetoclax
Venetoclax combined with decitabine or azacitidine in . . . - PubMed Older patients with acute myeloid leukemia (AML) respond poorly to standard induction therapy B-cell lymphoma 2 (BCL-2) overexpression is implicated in survival of AML cells and treatment resistance We report safety and efficacy of venetoclax with decitabine or azacitidine from a large, multicenter, phase 1b dose-escalation and expansion study
New Protocol: Venetoclax with Decitabine for AML Induction in Fit . . . Phase 2b, multicenter, randomized, open-label, noninferiority trial (NCT05177731) Young (18–59 yrs), newly diagnosed, fit AML patients eligible for intensive chemotherapy Venetoclax + decitabine (VEN-DEC) vs idarubicin + cytarabine (IA-12)
Protocol - The New England Journal of Medicine Protocol for: DiNardo CD, Jonas BA, Pullarkat V, et al Azacitidine and venetoclax in previously untreated acute myeloid leukemia N Engl J Med 2020;383:617-29 DOI: 10 1056 NEJMoa2012971
Less Is More: New Treatment Protocol for MDS and AML Is as Effective . . . While venetoclax is an oral medication, decitabine is given intravenously, requiring a daily visit to an infusion center As is now more common for cancer treatments, we were eager to see if we could reduce the toxicity of treatment while maintaining clinical efficacy
A Metabolically Optimized, Noncytotoxic Low-Dose Weekly Decitabine . . . Venetoclax (VEN) added to the hypomethylating agents (HMA) decitabine or azacitidine is the new standard of care for elderly patients with acute myeloid leukemia (AML) and is being evaluated in myelodysplastic syndrome (MDS) Current dosing of HMA VEN relies on leukemia suppression through cytotoxicity which also impacts normal hematopoiesis A regimen using once-weekly low-dose decitabine