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Influence of Curvature on Cell Motility and Morphology during Cancer . . . Curvature varies widely along curved microchannels, while its influence on cell migration remains elusive Here, we recapitulated the curved microchannels, as observed in clinical tumor tissues with hydrogels, and studied how cancer cells respond to curvature
西安交通大学刘燕新发现：曲率对受限微通道中肿瘤迁移过程中细胞运动和形态的影响 Influence of Curvature on Cell Motility and Morphology during Cancer Migration in Confined Microchannels Liu Yan; Zhao Tianyu; Xu Zhao; Dai Ningman; Zhao Qiang; Liang Yutong; Geng Songmei; Lei Ming; Xu Feng; Wang Lin; Cheng Bo
期刊论文-西安交通大学仿生工程与生物力学研究所 Meng Wang, Bo Cheng, Yaowei Yang, Han Liu, Guoyou Huang, Lichun Han, Fei Li, Feng Xu, Microchannel stiffness and confinement jointly induce the mesenchymal-amoeboid transition of cancer cell
Exploration of Curvature and Stiffness Dual-Regulated Breast Cancer . . . We found that the cell migration velocity was negatively correlated to curvature and positively correlated to stiffness In addition, curvature was investigated to influence the focal adhesion expression as well as the assignment of F-actin at the molecular level
Curvature dynamically regulates cell migration mode and motility To study the effect of curvature in a systematic and high-throughput manner, we developed a microfabricated chip containing arrays of concave and convex structures with a wide range of types and sizes (μm to mm) and investigated cell migration behavior on these structures
Substrate Curvature Regulates Cell Migration - PMC In this work, we study how substrate curvature at micrometer scale regulates cell motility We have developed a 3D mechanical model of single cell migration and simulated migration on curved substrates with different curvatures The simulation results show that cell migration is more persistent on concave surfaces than on convex surfaces
Physical confinement during cancer cell migration triggers therapeutic . . . In this study, we report that physically tight confinement during cancer cell migration triggers therapeutic resistance and induces cancer stem cell-like behavior including up-regulation in efflux proteins and in cancer stem cell related markers