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Sphingolipids in cardiovascular diseases and metabolic disorders Many investigations suggest the pivotal role of sphingolipids in the pathogenesis of lifestyle diseases such as myocardial infarction, hypertension, stroke, diabetes mellitus type 2 and obesity Some studies suggest that sphingolipids are important factors in cellular signal transduction
Sphingolipidoses - Wikipedia Sphingolipidoses are a class of lipid storage disorders or degenerative storage disorders caused by deficiency of an enzyme that is required for the catabolism of lipids that contain ceramide, [1] also relating to sphingolipid metabolism
Sphingolipidoses: Symptoms, Causes Treatment The treatment of sphingolipidoses is complex and varies depending on the type and severity of the disorder Current treatment strategies focus on managing symptoms and slowing disease progression
Sphingolipids and Cholesterol | SpringerLink A relatively well-controlled study also indicated that in humans, 1 g day of dietary SM does not alter the blood lipid profile except for an increased HDL-cholesterol concentration and has no effect on cholesterol absorption, synthesis, and intraluminal solubilization compared to control [112]
Cholesteryl Ester Storage Disease and Wolman Disease Cholesteryl ester storage disease and Wolman disease are sphingolipidoses, an inherited disorder of metabolism, caused by lysosomal acid lipase deficiency resulting in hyperlipidemia and hepatomegaly
Hyperlipidemia Vs Hypercholesterolemia: What’s The Difference Understanding the differences between hyperlipidemia and hypercholesterolemia is crucial for effective management and prevention of cardiovascular diseases While both conditions involve elevated lipid levels, hyperlipidemia encompasses a broader range of lipids, whereas hypercholesterolemia specifically refers to high cholesterol levels
Sphingolipid lysosomal storage diseases: from bench to bedside Defects in SL catabolism can cause the accumulation of SLs, leading to many types of lysosomal storage diseases (LSDs) collectively called sphingolipidoses These diseases mainly impact the neuronal and immune systems, but other systems can be affected as well
Secondary causes of dyslipidemia - UpToDate In many patients, hyperlipidemia is caused by some underlying "nonlipid" etiology rather than a primary disorder of lipoprotein metabolism The secondary causes of dyslipidemia will be reviewed briefly here Primary lipid disorders are discussed separately
SPHINGOLIPIDOSES - جامعة المجمعة Learning Objective Enlist the disorders with their respective enzyme deficiencies Discuss pathology of the Sphingolipidoses Explain the presentation and progression Describe principles of management