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Bioavailability of an R-α-Lipoic Acid γ-Cyclodextrin Complex in Healthy . . . It has been recently shown that complexation of R-LA with γ-CD significantly improved the bioavailability of R-LA in rats by enhancing intestinal absorption [26] However, there are no reports of the pharmacokinetic profile of the stabilized R-LA CD in human subjects
Enhancement of Oral Bioavailability of Functional Ingredients by . . . To stabilize RALA, complexation with γ-CD was investigated RALA was unstable molecule, whereas RALA-γCD complex was stable under the acidic conditions of the stomach and was easily absorbed in the intestine CD complexation is a promising technology as a formulation aid for oral delivery of insoluble or unstable ingredients such as CoQ10 and RALA
Spectroscopic Studies of R(+)-α-Lipoic Acid—Cyclodextrin Complexes - PMC We have recently shown that it is possible to stabilize RALA through complex formation with γ-CD yielding RALA-CD In the previous work we investigated the physicochemical properties of RALA-CD complexes using DSC, SEM, XRD and HPLC analysis; however, the interaction between the host and guest was not investigated in the solid state [22, 23]
Bioavailability of an R-α-Lipoic Acid γ-Cyclodextrin Complex . . . - MDPI It has been recently shown that complexation of R-LA with γ-CD significantly improved the bioavailability of R-LA in rats by enhancing intestinal absorption [26] However, there are no reports of the pharmacokinetic profile of the stabilized R-LA CD in human subjects