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Islet transplantation in seven patients with type 1 diabetes . . . Our observations in patients with type 1 diabetes indicate that islet transplantation can result in insulin independence with excellent metabolic control when glucocorticoid-free immunosuppression is combined with the infusion of an adequate islet mass
Islet Transplantation in Type 1 Diabetes Mellitus Using . . . These results demonstrate that transplantation of cultured human islet allografts results in reproducible insulin independence in all subjects under this immunosuppressive regimen, comparable to that of freshly transplanted islets (Edmonton protocol)
Islet Transplantation in Type I Diabetes Mellitus - PMC The landmark trial of islet transplantation in 2000 by the Edmonton group demonstrated successful reversal of diabetes in seven consecutive type I diabetes patients The trial utilized induction immunosuppression with daclizumab (a monoclonal antibody to the IL-2 receptor) and maintenance with a glucocorticoid-free immunosuppressive regimen
Islet Transplantation in Seven Patients with Type 1 Diabetes . . . Methods Seven consecutive patients with type 1 diabetes and a history of severe hypoglycemia and metabolic instability underwent islet transplantation in conjunction with a glucocorticoid-free immunosup-pressive regimen consisting of sirolimus, tacrolimus, and daclizumab
Islet transplantation in type 1 diabetes mellitus | CMAJ Design: In a nonrandomized, uncontrolled study 7 patients with type 1 diabetes for at least 5 years and a history of recurrent severe hypoglycemia or severe metabolic instability underwent islet transplantation in conjunction with an immunosuppressive regimen of sirolimus, tacrolimus and daclizumab Prophylactic antibiotics and vitamins were
Simultaneous islet and kidney transplantation in seven . . . Research design and methods: Seven patients with type 1 diabetes and end-stage renal failure were transplanted with allogenic islets and kidneys procured from brain-dead donors To prevent organ rejection, patients received alemtuzumab for induction immunosuppression, followed by sirolimus and tacrolimus