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Cure Consortium CKDu CURE Consortium The Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium, funded by the National Institutes of Health (NIH), is a collaborative research consortium that brings together a broad range of expertise and enables discovery science to understand the causes of CKDu and risk factors for disease progression of CKDu
What is CKDu? - International Society of Nephrology What is CKDu? CKDu or Chronic Kidney Disease of Unknown etiology Uncertain cause is a type of chronic kidney disease that mainly affects marginalized agricultural communities in specific areas of the world where a large number of people develop an unexplained, deadly form of kidney disease (Figure 1 Distribution in the world) Because the populations affected are some of the world’s poorest
Chronic Kidney Disease of Undetermined Etiology around the World This review focuses on the current understanding of CKDu by analyzing epidemiology, potential risk factors, and clinical and pathological features as well as geographical peculiarities of each disease We also focus our attention on the etiology of these conditions in which multiple factors may syne …
Chronic Kidney Disease of Unknown Origin: A Mysterious Epidemic Amongst the many threats to health in our world, the most challenging ones are the ones with unknown causes There is a mysterious epidemic of kidney disease called chronic kidney disease of unknown etiology (CKDu) that is occurring in many parts of
AJKD Atlas of Renal Pathology: CKD of Unknown Cause (CKDu . . . CKDu describes endemic chronic kidney disease without known etiology, most commonly occurring in developing countries In Central America, the term Mesoamerican nephropathy (MeN) has been used MeN is slowly progressive and mostly affects male agricultural workers of Central America, with most patients between the ages of 20 and 60 years In endemic regions in Central America, up to 20% of men
CKDu: the known unknowns | Pediatric Nephrology - Springer A study from Leibler et al in this issue of Paediatric Nephrology challenges current theories about the aetiology of CKDu and demands urgent attention from the international nephrology community to address a global disease in vulnerable, economically disadvantaged people The authors report a cross-sectional study of 210 youths, aged 7–17 years residing predominantly in a CKDu endemic
Demystifying Chronic Kidney Disease of Unknown Etiology (CKDu . . . Abstract Chronic kidney disease of unknown etiology (CKDu) has been recognized as a global non-communicable health issue There are many proposed risk factors for CKDu and the exact reason is yet to be discovered Understanding the inhibition or manipulation of vital renal enzymes by pesticides can play a key role in understanding the link between CKDu and pesticides Even though it is very
Global dimensions of chronic kidney disease of unknown etiology (CKDu . . . Diabetes and hypertension are the predominant risk factors for chronic kidney disease (CKD) globally Infectious diseases resulting in glomerulonephritis are also important in low-income countries [1, 2] However, in the past two decades, a severe form of CKD has been reported in individuals without these risk factors CKD of unknown etiology (CKDu) affects adults in their third to fifth
About CURE - CKDu CURE Consortium Chronic kidney disease (CKD) is most common in older persons (age>60), affects both sexes equally, and is primarily due to diabetes and hypertension However, an increasingly common form of early onset CKD called "chronic kidney disease of uncertain etiology (CKDu), due to the fact that the cause (or causes) are unknown, disproportionately affects males at younger ages and cannot be attributed