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Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene . . . This review evaluates several of the ongoing and future directions of combining next-generation CRISPR-Cas9 gene editing with synthetic biology to optimize CAR T-cell therapy for future clinical trials toward the establishment of a new cancer treatment paradigm
CRISPR Cas9: A Powerful Strategy to Improve CAR-T Cell Persistence As an emerging treatment strategy for malignant tumors, chimeric antigen receptor T (CAR-T) cell therapy has been widely used in clinical practice, and its efficacy has been markedly improved in the past decade
Boosting CAR-T cell therapy with CRISPR technology We first provide an overview of CAR-T cell therapy and CRISPR technology, followed by discussions on how CRISPR and its related technologies can be adopted to tackle various issues associated with CAR-T cell therapy, either via knockout knockin of specific genes or CRISPR-based screening
Combination of CRISPR Cas9 System and CAR-T Cell Therapy: A . . . - PubMed The application of CRISPR Cas9 to CAR-T cell therapy has shown promising clinical results with minimal toxicity In this review, we summarized the past achievements of CRISPR Cas9 in CAR-T therapy and focused on the potential CAR-T targets
CRISPR CAR-T cells: Edited T Cells Are Revolutionizing Cancer Treatment CAR-T Therapies and CRISPR are Fighting Cancer and Revolutionizing Medicine Cancer is the second leading cause of death in the United States, taking half a million lives each year CAR T technology has successfully harnessed the human immune system to produce awe-inspiring cancer remission rates
CRISPR–Cas9 applications in T cells and adoptive T cell therapies Emerging researches reveal that clustered regularly interspaced palindromic repeats–associated protein 9 (CRISPR–Cas9) genome editing has enabled T cells to be more adaptable to specific microenvironments, opening the door to advanced T cell therapies in preclinical and clinical trials
CRISPR Cas-based CAR-T cells: production and application Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment approach for cancer, autoimmune disease, and heart disease The integration of CAR into T cells is typically facilitated by retroviral or lentiviral vectors
Innovative approaches to CAR-T cell therapy: the role of lipid . . . The efficient response structure of chimeric antigen receptor T (CAR-T) cells has led to significant success in the treatment of hematological malignancies However, when confronted with the challenges associated with solid tumors, CAR-T cells have increasingly exhibited limitations, including inadequate infiltration and a shortened lifespan Consequently, enhancing CAR-T cells to broaden