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Aldosterone and the Risk of Hypertension - PMC Aldosterone, the key hormone in the mineralocorticoid pathway, plays a fundamental role in salt and water homeostasis, blood pressure regulation, and cardiovascular remodeling Both genomic and non-genomic mechanisms influence aldosterone-induced renal sodium reabsorption
The Role of Aldosterone in Obesity-Related Hypertension In obese subjects, both salt sensitivity of BP, enhanced by obesity-related metabolic disorders including aldosterone excess, and increased dietary sodium intake are closely related to the incidence of hypertension
Salt and Aldosterone | Hypertension - AHA ASA Journals It may be that, by blocking aldosterone, which often remains inexplicably high in many hypertensive patients, and in particular patients with resistant hypertension, mineralocorticoid receptor antagonists may prove effective in offsetting some of the end-organ effects of high dietary sodium intake
Hypertension in Primary Aldosteronism Is Initiated by Salt-Induced . . . Aldosterone promoted salt sensitivity and initiation of salt-dependent hypertension by amplifying salt-induced increases in SVR while decreasing CO Increases in CO are not required for the initiation or maintenance of hypertension
The Kidneys and Aldosterone Mineralocorticoid Receptor System in Salt . . . The partnership between aldosterone and MR in the kidneys plays a central role in the physiological response to variations in dietary salt intake In addition, aldosterone, or activation of MR, is now recognized as an important mediator of hypertension-associated target organ damage