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Chimeric antigen receptor T-cell therapy for T-cell acute . . . Chimeric antigen receptor (CAR) T-cell therapy is a new and effective treatment for patients with hematologic malignancies Clinical responses to CAR T cells in leukemia, lymphoma, and multiple myeloma have provided strong evidence of the antitumor activity of these cells
Fratricide-resistant CD7-CAR T cells in T-ALL - Nature Medicine We report a case series of 17 such patients who received autologous chimeric antigen receptor (CAR) T cells expressing an anti-CD7 CAR and an anti-CD7 protein expression blocker (PEBL), which
CAR T-cells for T-cell acute lymphoblastic leukemia CAR T-cells targeting CD19 antigen is a promising cancer immunotherapy obtaining excellent response rate in patients heavily pretreated for multiple relapses or chemo-resistant B cell leukemia and lymphoma
CARTALL: Chimeric-Antigen Receptor (CAR) T-Cell Therapy for . . . Patients with > 99% CD7 expression on blast cells will be eligible for anti-CD7 PEBL-CAR-T cell infusion This is a single-centre, phase I study to determine the efficacy and safety of CAR T-cell therapy in patients with high-risk T-ALL, refractory or relapsed T-ALL
Targeted CD7 CAR T-cells for treatment of T-Lymphocyte . . . Chimeric antigen receptor (CAR) T-cell therapy is a novel cell-based immunotherapy that has attracted considerable attention from researchers and healthcare professionals due to its outstanding therapeutic efficacy (1)