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Enzalutamide: Prostate Cancer Treatment Uses, Side Effects Enzalutamide is a medication used to treat prostate cancer in adult males Common side effects of enzalutamide include fatigue, weakness, decrease in hemoglobin level, decrease in count of neutrophil immune cells, decrease in white blood cell count, high blood glucose level (hyperglycemia), electrolyte disturbances, back pain, joint pain (arthralgia), musculoskeletal pain, muscular weakness