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ZIP Code: Postal Code:
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5043856266 (+1-504-385-6266)
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5043856268 (+1-504-385-6268)
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USA SIC Code(Standard Industrial Classification Code):
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Cell Systems: Cell Press Cell Systems publishes peer-reviewed articles that address fundamental questions in systems biology
Issue: Cell Systems In this issue of Cell Systems, Pentimalli et al extend imaging-based spatial transcriptomics to 3D and combine it with ECM profiling The multimodal analysis of cellular neighborhoods in a clinical lung adenocarcinoma sample revealed potential molecular drivers of tumor progression, ECM remodeling, and immune escape
Aims and scope: Cell Systems - Cell Press Cell Systems was established in 2015 to provide a home at Cell Press for elegant work that addresses fundamental questions in systems biology "Systems biology," as we broadly define it, is work that develops a rigorous understanding of any biological phenomenon where one plus one does not apparently equal two
New articles: Cell Systems Here, we developed two statistical models that accurately describe the distributions of cell counts for multiplexed imaging data analysis These models link cell spatial patterns to statistical distribution parameters and provide improved statistical tests compared with commonly used non-parametric rank-based tests
Model-guided design of microRNA-based gene circuits . . . - Cell Press Unlike the single-transcript model depicted in Figure 3A, in these systems, mature output mRNA is not produced by transcription and splicing of the primary transcript Instead, it is produced directly from transcription of a second gene with transcription rate α RNA
Proliferation history and transcription factor levels . . . - Cell Press By tailoring the cocktail to a minimal set of transcripts, we reduce extrinsic variation, allowing us to examine how proliferation and TFs synergistically drive conversion We show that cell state—as set by proliferation history—defines how cells interpret the levels of TFs
Scalable image-based visualization and alignment of . . . - Cell Press Image data is typically stored in n-dimensional, integer-based Cartesian coordinate systems that are natively supported by most camera chips and display devices In contrast, spatial sequencing data consist of measurements at arbitrary, floating-point precise locations, which stem from accurately localizing sequenced locations
Cell Press: Cell Systems This is a collection of exemplary methods published by Cell Systems, led by our Editorial discussing methods’ fundamental importance
Joint analysis of chromatin accessibility and gene . . . - Cell Press Here, we present paired analysis of RNA and accessible chromatin in the same single cell by sequencing (Parallel-seq), a single-cell analysis technique that combines combinatorial indexing and droplet-based single-cell sequencing (dsc-seq) to simultaneously measure chromatin accessibility and gene expression in the same cell (i e , joint scATAC