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Pyridines - DrugBank Online Compounds with a six membered aromatic ring containing NITROGEN The saturated version is PIPERIDINES Investigated for use treatment in solid tumors A pediculicide metalloproteinase used topically in the treatment of head lice infection A medication used to treat HR+ HER2- advanced or metastatic breast cancer
Pyridine: the scaffolds with significant clinical diversity Topical isolation of the structurally-modified natural products diploclinide and nakinadine contain pyridine moiety Atazanavir (Rey-ataz) and imatinib mesylate (Gleevec) are medicinally-active pyridine derivatives
Pyridine - Molecule of the Month - July 2025 (HTML version) Why is Pyridine Mid-Table? The molecules above pyridine in the table , for example piperidine, contain sp3 -hybridised nitrogen atoms, which affects their basicity Pyridine's moderate pK a is due to the nitrogen being part of the aromatic ring, which makes its lone-pair of electrons less available for protonation
Naturally Isolated Pyridine Compounds Having Pharmaceutical . . . Pyridine-based natural products consist of a variety of interesting compounds with diverse structures that originate from the five kingdoms of life Nicotine, niacin (vitamin B 3 or nicotinic acid), and pyridoxine (vitamin B 6) are extreme recognized compounds with an aromatic π electron pyridine moiety (Figure 1)
Pyridine Compounds with Antimicrobial and Antiviral Activities Pyridine is a privileged nucleus among heterocycles; its compounds have been noted for their therapeutic properties, such as antimicrobial, antiviral, antitumor, analgesic, anticonvulsant, anti-inflammatory, antioxidant, anti-Alzheimer’s, anti-ulcer or antidiabetic
Pyridines - Chemistry Online Pyridine is a colorless liquid that boils at 115 ºC It used to be obtained almost exclusively from coal tar Today, it is obtained industrially from ammonia and acetylene Pyridine like benzene has 6 π electrons (aromatic Hückel) Its structure is planar with bond angles of 120º
15. 5: Aromatic Heterocycles - Pyridine and Pyrrole Pyridine is an example of a six-membered aromatic heterocycle and has an electronic structure similar to benzene In the bonding picture of pyridine the five carbons and single nitrogen are all sp2 hybridized